Balcı Tansel Ansal, Koç Zehra Pınar, Mitil Hüseyin Aydın
Firat University Faculty of Medicine, Nuclear Medicine Department, Elazig, Turkey.
Mol Imaging Radionucl Ther. 2011 Aug;20(2):59-62. doi: 10.4274/MIRT.6. Epub 2011 Aug 1.
The effect of Celiac Disease (CD) on children's bone is the decrease in bone mineral density (BMD). Osteoporosis is a consequence of this decrease and usually manifests in adult ages. Studies in CD patients generally show that bone density of these patients can be different at the same ages for the same duration of disease. The aim of this study is to investigate the relationship between age and bone mineral density of CD patients at first diagnosis.
Ninety one patients (M/F: 36/55; age range: 3-16; mean age: 9.6±3.5) with diagnosis of CD were included in the study. BMD survey from L1-L4 lumbar spine and total hip of the patients was evaluated at presentation. We evaluated the patients in 3 groups according to their ages: Group 1: pre-school (3-7 years old), Group 2: elementary school (8-11 years old) and Group 3: adolescent (12-16 years old). RESULTS were compared using Student's t test and correlation analysis.
The mean disease duration of the patients was 16.4±16.3 months. Mean height and weight of the patients were 124.8±17.9 cm and 27±9.3 kg, respectively and height and weight of 37 patients were in ≤ 3. percentile according to age. The BMD values of both lumbar spine and total hip and Z-scores of lumbar region were in mild correlation with age (r>0.5). There was significant difference between mean ages of patients with low bone mass for chronological age and normal bone densitometry values (p<0.05). There were 27, 36 and 28 patients in Group 1, Group 2 and Group 3, respectively. The difference between mean BMD values of these groups were statistically significant (p<0.05). The mean values of lumbar Z- scores of patients were -1.08±1.27, -1.42±1, -1.86±1.14, respectively for these three groups.
Bone mineral densities of CD patients in childhood were lower in elder children at the time of diagnosis. This confirms the opinion that the diagnosis at earlier age results better treatment chance before bone mineral loss appears in CD patients.
None declared.
乳糜泻（CD）对儿童骨骼的影响是骨矿物质密度（BMD）降低。骨质疏松是这种降低的结果，通常在成年期出现。对CD患者的研究一般表明，这些患者在相同病程的相同年龄时骨密度可能不同。本研究的目的是调查初诊时CD患者年龄与骨矿物质密度之间的关系。
本研究纳入了91例确诊为CD的患者（男/女：36/55；年龄范围：3 - 16岁；平均年龄：9.6±3.5岁）。在患者就诊时评估其L1 - L4腰椎和全髋部的骨密度。根据年龄将患者分为3组：第1组：学龄前儿童（3 - 7岁），第2组：小学生（8 - 11岁），第3组：青少年（12 - 16岁）。采用学生t检验和相关性分析比较结果。
患者的平均病程为16.4±16.3个月。患者的平均身高和体重分别为124.8±17.9厘米和27±9.3千克，37例患者的身高和体重按年龄处于≤第3百分位数。腰椎和全髋部的骨密度值以及腰椎区域的Z值与年龄呈轻度相关性（r>0.5）。按实际年龄计算骨量低但骨密度测量值正常的患者的平均年龄之间存在显著差异（p<0.05）。第1组、第2组和第3组分别有27例、36例和28例患者。这些组的平均骨密度值差异具有统计学意义（p<0.05）。这三组患者腰椎Z值的平均值分别为 - 1.08±1.27、 - 1.42±1、 - 1.86±1.14。
儿童CD患者在诊断时年龄较大者的骨矿物质密度较低。这证实了在CD患者骨矿物质流失出现之前更早诊断会带来更好治疗机会的观点。
未声明。
