Gong Yi, Yang Jin
Student Brigade, Third Military Medical University, Chongqing 400038, China.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2013 Feb;30(1):213-6.
A common DNA polymerase can replicate DNA which functions normally. However, if DNA suffers damage, the genome can not be replicated by a common DNA polymerase because DNA lesions will block the replication apparatus. Another kind of DNA polymerases in organism, Y-family DNA polymerases which is also called translesion synthesis (TLS) polymerases, can deal with this problem. Their main functions are bypassing the lesions in DNA, replicating the genome and saving the dying cells. This thesis presents a historical review of the literature pertinent to the structure, functions and roles of Y-family DNA polymerases.
一种常见的DNA聚合酶能够复制正常发挥功能的DNA。然而，如果DNA受到损伤，普通的DNA聚合酶就无法复制基因组，因为DNA损伤会阻碍复制机制。生物体内的另一类DNA聚合酶，即Y家族DNA聚合酶（也称为跨损伤合成（TLS）聚合酶），可以解决这个问题。它们的主要功能是绕过DNA中的损伤、复制基因组并挽救濒死细胞。本文对与Y家族DNA聚合酶的结构、功能和作用相关的文献进行了历史性综述。
