Sielski Janusz, Janion-Sadowska Agnieszka
Swietokrzyskie Centrum Kardiologii w Kielcach, Oddzial Kardiologii.
Pol Merkur Lekarski. 2013 Jan;34(199):9-13.
Aberrant waveform during artificial pacing increases secretion of natriuretic peptides, mainly B-type natriuretic peptide (BNP). The aim of the study was to investigate whether renal function is modified through increased BNP secretion during artificial pacing.
A total of 117 patients with pacemaker implanted were included (pacing mode: AAI/R - 21, DDD/R - 59, VVWl/R - 37) and 48 healthy volunteers served as controls. Serum BNP, creatinine and urea, levels were measured prior to, three and six months after pacemaker implantation.
Three and six months after implantation BNP level significantly increased in DDD/R group, urea level increased in AAI/R group whereas creatinine level increased in DDD/R and WI/R group.
In patients after pacemaker implantation BNP level increases in DDD/R pacing mode group whereas in other modes it remains stable. Pacemaker implantation leads to changes in renal function. B-type natriuretic peptide level may serve as a useful parameter forrenal and cardiac function assessment after pacemaker implantation.
人工起搏期间异常波形会增加利钠肽的分泌，主要是B型利钠肽（BNP）。本研究的目的是调查人工起搏期间BNP分泌增加是否会改变肾功能。
共纳入117例植入起搏器的患者（起搏模式：AAI/R - 21例，DDD/R - 59例，VVWl/R - 37例），48名健康志愿者作为对照。在起搏器植入前、植入后3个月和6个月测量血清BNP、肌酐和尿素水平。
植入后3个月和6个月，DDD/R组BNP水平显著升高，AAI/R组尿素水平升高，而DDD/R组和WI/R组肌酐水平升高。
起搏器植入后，DDD/R起搏模式组BNP水平升高，而其他模式下保持稳定。起搏器植入导致肾功能改变。B型利钠肽水平可能是起搏器植入后评估肾脏和心脏功能的有用参数。
