Blecharz Paweł, Reinfuss Marian, Jakubowicz Jerzy, Piotr Skotnicki, Wysocki Wojciech, Karolewski Kazimierz, Urbański Krzysztof
Gynaecology Department, Centre of Oncology, Maria Sklodowska-Curie Memorial Institute, Krakow Branch, Poland.
Ginekol Pol. 2012 Dec;83(12):904-9.
Aim of the study was the assessment of prognostic factors in the group of primary invasive vaginal carcinoma (PIVC) patients subjected to radical radiation therapy
The analysis was performed for the group of 152 PIVC patients treated with intracavitary brachytherapy alone (16.5%), the combination of brachytherapy and external radiotherapy (78.9%), or external radiotherapy alone (4.6%). The relationship was investigated between treatment outcome and the following demographic, clinical and histopathological features: age, duration of pathological symptoms, number of births given, prior hysterectomy haemoglobin level, Karnofsky performance status score, primary tumour location in vagina, length of vagina involved, FIGO stage, gross appearance, histological type, and tumour grade.
Five-year disease-free survival was observed in 46.1% of the patients (70/152). Patients below 60 years of age, with Karnofsky score of 80-90, diagnosed with PIVC in stage 10 or 110, and with tumour of grade G1 or G2 had significantly higher 5-year disease-free survival. Multifactoral analysis showed that age below 60 and FIGO stage 10 and 110 are independent favourable prognostic factors.
The independent prognostic factors in PIVC patients treated with radical radiotherapy are patient age and FIGO stage.
本研究旨在评估接受根治性放射治疗的原发性浸润性阴道癌（PIVC）患者的预后因素。
对152例PIVC患者进行分析，这些患者单独接受腔内近距离放射治疗（16.5%）、近距离放射治疗与外照射放疗联合治疗（78.9%）或仅接受外照射放疗（4.6%）。研究了治疗结果与以下人口统计学、临床和组织病理学特征之间的关系：年龄、病理症状持续时间、生育次数、既往子宫切除术后血红蛋白水平、卡诺夫斯基功能状态评分、阴道原发性肿瘤位置、受累阴道长度、国际妇产科联盟（FIGO）分期、大体外观、组织学类型和肿瘤分级。
46.1%的患者（70/152）观察到5年无病生存率。年龄低于60岁、卡诺夫斯基评分为80 - 90、诊断为FIGO Ⅰ期或Ⅱ期PIVC且肿瘤分级为G1或G2的患者5年无病生存率显著更高。多因素分析表明，年龄低于60岁以及FIGO Ⅰ期和Ⅱ期是独立的有利预后因素。
接受根治性放疗的PIVC患者的独立预后因素是患者年龄和FIGO分期。
