Urbański K, Kojs Z, Reinfuss M, Fabisiak W
Department of Gynecologic Oncology, Maria Skłodowska-Curie Memorial Institute, Kraków, Poland.
Gynecol Oncol. 1996 Jan;60(1):16-21. doi: 10.1006/gyno.1996.0004.
Between 1965 and 1988, 125 patients with primary invasive vaginal carcinoma were treated with radiation therapy at the Center of Oncology in Kraków. Twenty-two superficial stage I patients received radium or cesium intracavitary radiation alone. The remaining 11 patients with stage I disease whose lesions were either large or thick and 77 patients with stages II and III were treated with a combination of external irradiation followed by intracavitary brachytherapy. Fifteen patients with stage IVA received external irradiation only. Five-year NED survival was achieved in 42.4% of patients. In the Cox multivariate analysis three variable were independently related to beneficial survival: grade G1 + G2, stage I + II, and age below 60 years. Of 66 patients who died of vaginal cancer, locoregional failure was found in 51 (77.3%), locoregional and distant in 5 (7.6%), and distant only in 10 (15.1%) patients. Late radiation morbidity occurred in 16 (12.8%) patients.
1965年至1988年间，克拉科夫肿瘤中心对125例原发性浸润性阴道癌患者进行了放射治疗。22例浅表I期患者仅接受了镭或铯腔内放疗。其余11例I期病变较大或较厚的患者以及77例II期和III期患者接受了外照射联合腔内近距离放疗。15例IVA期患者仅接受了外照射。42.4%的患者实现了5年无疾病生存。在Cox多变量分析中，三个变量与良好生存独立相关：G1+G2级、I+II期和60岁以下年龄。在66例死于阴道癌的患者中，51例（77.3%）出现局部区域失败，5例（7.6%）出现局部区域和远处转移，仅10例（15.1%）患者出现远处转移。16例（12.8%）患者发生了晚期放射并发症。
