School of Pharmaceutical Sciences, Mukogawa Women's University, Nishinomiya City, Japan.
J Pharm Pharmacol. 2013 Apr;65(4):503-11. doi: 10.1111/jphp.12009. Epub 2012 Nov 22.
Aminoleban® EN is a bitter total enteral nutrient product with an unpleasant odour. The purpose of this study was to evaluate the odour of Aminoleban® EN, taste-masked with various flavoured powders, by human testing and by using an electronic nose system (Alpha M.O.S.).
Initially, the odour of Aminoleban® EN alone at various concentrations was evaluated. Secondly, the odour of Aminoleban® EN with the addition of various flavoured powders was evaluated; the evaluation included data on odour intensity, preference levels and evoked taste image.
With the human nose, a concentration of 0.43 g/100 ml seemed to be the taste threshold for Aminoleban® EN. In the electronic nose system, principal component analysis revealed that concentrations over 0.39 g/100 ml Aminoleban® EN could be distinguished from water. It was clear from both human testing and using the electronic nose system that the unpleasant odour of Aminoleban® EN could be masked by pineapple- and plum-flavoured powders, both of which contain not only sweet but also sour components.
The electronic nose system may be useful for detecting odours at or below the level detectable by the human olfactory system and for classifying the quality of different odours, thus reducing the amount of human testing required.
Aminoleban® EN 是一种有苦味的全肠内营养产品,具有难闻的气味。本研究的目的是通过人体测试和使用电子鼻系统(Alpha M.O.S.)评估 Aminoleban® EN 的气味,该产品用各种调味粉进行了掩味处理。
首先,评估了不同浓度的 Aminoleban® EN 单独的气味。其次,评估了添加各种调味粉的 Aminoleban® EN 的气味;评估包括气味强度、偏好水平和诱发味觉图像的数据。
用人类的鼻子,0.43g/100ml 的浓度似乎是 Aminoleban® EN 的味觉阈值。在电子鼻系统中,主成分分析表明,浓度超过 0.39g/100ml 的 Aminoleban® EN 可以与水区分开来。无论是人体测试还是使用电子鼻系统,都清楚地表明,菠萝味和李梅味的调味粉都可以掩盖 Aminoleban® EN 的难闻气味,这两种调味粉不仅含有甜味成分,还含有酸味成分。
电子鼻系统可用于检测人类嗅觉系统可检测到或以下水平的气味,并可用于对不同气味的质量进行分类,从而减少所需的人体测试量。