Research Group Functional Genomics and Proteomics, K.U. Leuven, Naamsestraat 59, 3000 Leuven, Belgium +32 16 324260 ; +32 16 323902 ;
Expert Opin Drug Discov. 2008 Apr;3(4):425-40. doi: 10.1517/17460441.3.4.425.
Because of their wide range of functions, endogenous peptides have great potential either as drugs themselves or as drug targets.
To provide an overview of the current use of peptides as drugs (targets) and describe how improvements in peptide biochemistry and the application of peptidomics studies can lead to the discovery of new diagnostic and therapeutic targets.
We discuss the different peptidomics technologies and their application in the study of human and animal disease models, animal venoms, antimicrobial peptides, G-protein-coupled receptor ligands and biomarkers.
RESULTS/CONCLUSIONS: At present, peptide drugs represent a small but growing number of pharmaceutical molecules. The peptidomics methodology, which was introduced 7 years ago to study naturally occurring peptides, will lead to a plethora of new peptide drug leads.
由于内源性肽具有广泛的功能，因此它们具有作为药物本身或作为药物靶点的巨大潜力。
概述目前将肽用作药物（靶点）的情况，并描述肽化学的改进和肽组学研究的应用如何导致新的诊断和治疗靶点的发现。
我们讨论了不同的肽组学技术及其在人类和动物疾病模型、动物毒液、抗菌肽、G 蛋白偶联受体配体和生物标志物研究中的应用。
结果/结论：目前，肽类药物代表了一小部分但不断增长的药物分子。肽组学方法是 7 年前引入的，用于研究天然存在的肽，它将产生大量新的肽类药物先导物。
