Doria G, Cangemi F, Gulizia M, Lo Giudice P, Circo A
Reparto di Cardiologia P.O.U. S. Currò e S. Luigi G., USSL 34, Catania.
Minerva Cardioangiol. 1990 Mar;38(3):97-100.
The authors report the cases of three male patients, aged 36, 54 and 52 years, who developed gingival hypertrophy during treatment with nifedipine at a dose of 40 mg/daily. Hypertrophy was the same as that observed in patients treated with anti-convulsive or cytostatic drugs, and may probably be due to interference with calcium ions and local factors. Full recovery was achieved by suspending nifedipine treatment in all patients.
作者报告了3例男性患者的病例，年龄分别为36岁、54岁和52岁，他们在以每日40毫克的剂量服用硝苯地平治疗期间出现了牙龈增生。增生情况与接受抗惊厥或细胞抑制药物治疗的患者中观察到的相同，可能是由于钙离子干扰和局部因素所致。通过在所有患者中停用硝苯地平治疗，均实现了完全康复。
