纳米羟基磷灰石涂层对延长愈合期后骨整合的影响。
The influence of nano hydroxyapatite coating on osseointegration after extended healing periods.
机构信息
Department of Prosthodontics, Faculty of Odontology, Malmö University, Sweden.
出版信息
Dent Mater. 2013 May;29(5):514-20. doi: 10.1016/j.dental.2013.02.004. Epub 2013 Mar 13.
OBJECTIVE
Studies observing early wound healing periods around dental implants demonstrate an implants ability to enhance osseointegration, the bone-implant interactions for extended healing periods though have not been thoroughly studied.
METHODS
Twenty threaded titanium alloy (Ti6Al4V, Grade 5) implants were inserted bilaterally, half prepared to impart stable hydroxyapatite nanoparticles onto a sand blasted and acid etched surface (HA) and half with a non-coated control surface with only heat treatment (HT), into eighteen rabbit femurs. At 12 weeks, the bone-implant blocks were retrieved for micro computed tomography (μCT), histologic processing and histomorphometric evaluation.
RESULTS
The bone-to-implant contact for the entire threaded portion of the implant revealed 57.1% (21.0) for the HT group and 38.8% (17.7) for the HA group with a total bone area within the threads 72.5% (13.9) (HT) and 59.7% (12.5) (HA). The 3D reconstructed μCT image corresponded to the histomorphometric results.
SIGNIFICANCE
It is suggested that multiple factors such as the change in topography and chemistry may have influenced the outcomes.
目的
观察种植牙周围早期愈合期的研究表明，种植牙能够增强骨整合能力，尽管对于延长愈合期的骨-种植体相互作用尚未进行彻底研究。
方法
将 20 个螺纹钛合金（Ti6Al4V，等级 5）种植体双侧植入，一半采用喷砂酸蚀表面（HA）制备，以赋予稳定的羟基磷灰石纳米颗粒，另一半采用仅热处理（HT）的无涂层对照表面。在 12 周时，取出骨-种植体块进行微计算机断层扫描（μCT）、组织学处理和组织形态计量评估。
结果
整个种植体螺纹部分的骨-种植体接触，HT 组为 57.1%（21.0），HA 组为 38.8%（17.7），螺纹内总骨面积 HT 组为 72.5%（13.9），HA 组为 59.7%（12.5）。3D 重建的 μCT 图像与组织形态计量结果相对应。
意义
研究表明，多种因素，如形貌和化学性质的变化，可能影响了结果。
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