J Biol Regul Homeost Agents. 2013 Jan-Mar;27(1):247-51.
Our aim was to assess the prevalence of gastro protection in the Albanian population using non-steroidal anti-inflammatory drugs (NSAIDs). A cross-sectional study, conducted in November-December 2011 in Albania, included 610 NSAIDs users (236 men and 374 women) who visited pharmacies to receive their NSAID medication. A structured questionnaire was administered to all participants including information on age, sex, educational status, pathology being treated with NSAID, presence of gastrointestinal ulcer or related complications, duration of NSAIDs therapy, type of drug used, and gastro protection therapy. Almost all participants (N=599) received NSAIDs to treat rheumatic and/or musculoskeletal disorders. Of these, 475 individuals were on chronic therapy with high daily doses of NSAIDs. Concomitant gastro protective therapy was found in 184 individuals (30 percent of the overall sample). Women and the more educated individuals received more gastro protection than men and the low educated counterparts, respectively (33.4 percent in women vs 25 percent in men; 47 percent in highly educated vs 18 percent in low educated). Appropriate use of gastro protective therapy for NSAID users needs to be promptly implemented in Albania, as its inappropriate use raises ethical and economic concerns. Prescriptions should follow clear guidelines for prevention of gastrointestinal damage following NSAIDs therapy among persons at high risk.
我们的目的是使用非甾体抗炎药（NSAIDs）评估阿尔巴尼亚人群中的胃保护的流行情况。2011 年 11 月至 12 月在阿尔巴尼亚进行的一项横断面研究，共纳入 610 名 NSAIDs 使用者（236 名男性和 374 名女性），他们到药店领取 NSAID 药物。向所有参与者发放了一份结构式问卷，内容包括年龄、性别、教育程度、用 NSAID 治疗的疾病、是否存在胃肠道溃疡或相关并发症、NSAIDs 治疗持续时间、使用的药物类型以及胃保护治疗。几乎所有参与者（N=599）都因风湿和/或肌肉骨骼疾病而使用 NSAIDs。其中，475 人接受 NSAIDs 慢性治疗，每日剂量较高。在 184 名参与者中发现了联合胃保护治疗（占总体样本的 30％）。女性和受教育程度较高的人比男性和受教育程度较低的人接受更多的胃保护治疗（女性中为 33.4％，男性中为 25％；受高等教育的人为 47％，受低等教育的人为 18％）。在阿尔巴尼亚，需要及时实施针对 NSAID 用户的胃保护治疗的合理使用，因为其不合理使用会引起伦理和经济方面的关注。对于处于高风险的人群，在 NSAIDs 治疗后预防胃肠道损伤时，处方应遵循明确的指南。
