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本文引用的文献

1
Cross-sectional analysis of retrospective case series of hospitalisations for gastropathy caused by non-steroidal anti-inflammatory treatment: risk factors and gastroprotection use.非甾体抗炎治疗所致胃病住院病例系列的横断面回顾性分析:危险因素及胃保护措施的使用情况
Eur J Hosp Pharm. 2017 Nov;24(6):355-360. doi: 10.1136/ejhpharm-2016-001087. Epub 2016 Nov 7.
2
International Consensus on Guiding Recommendations for Management of Patients with Nonsteroidal Antiinflammatory Drugs Induced Gastropathy-ICON-G.非甾体抗炎药所致胃病患者管理指导建议国际共识-ICON-G
Euroasian J Hepatogastroenterol. 2018 Jul-Dec;8(2):148-160. doi: 10.5005/jp-journals-10018-1281. Epub 2019 Feb 1.
3
Use of Non-Steroidal Anti-Inflammatory Drugs and Associated Gastroprotection in a Cohort of Workers.非甾体抗炎药的使用及相关胃保护在工人队列中的应用。
Int J Environ Res Public Health. 2018 Aug 24;15(9):1836. doi: 10.3390/ijerph15091836.
4
Prescription audit of NSAIDs and gastroprotective strategy in elderly in primary care.基层医疗中老年人非甾体抗炎药的处方审核及胃保护策略
Int J Risk Saf Med. 2017;29(1-2):57-68. doi: 10.3233/JRS-170742.
5
Systematic review with network meta-analysis: comparative effectiveness and safety of strategies for preventing NSAID-associated gastrointestinal toxicity.系统评价与网络荟萃分析:预防 NSAID 相关胃肠道毒性的策略的比较有效性和安全性。
Aliment Pharmacol Ther. 2016 Jun;43(12):1262-75. doi: 10.1111/apt.13642. Epub 2016 Apr 28.
6
Safe prescribing of non-steroidal anti-inflammatory drugs in patients with osteoarthritis--an expert consensus addressing benefits as well as gastrointestinal and cardiovascular risks.骨关节炎患者非甾体抗炎药的安全处方——兼顾获益以及胃肠道和心血管风险的专家共识
BMC Med. 2015 Mar 19;13:55. doi: 10.1186/s12916-015-0285-8.
7
Time-trends in the prescribing of gastroprotective agents to primary care patients initiating low-dose aspirin or non-steroidal anti-inflammatory drugs: a population-based cohort study.对开始使用低剂量阿司匹林或非甾体抗炎药的基层医疗患者开具胃保护剂的时间趋势:一项基于人群的队列研究。
Br J Clin Pharmacol. 2015 Sep;80(3):589-98. doi: 10.1111/bcp.12626. Epub 2015 May 22.
8
Nonsteroidal anti-inflammatory drugs, gastroprotection, and benefit-risk.非甾体抗炎药、胃保护作用及获益风险
Pain Pract. 2014 Apr;14(4):378-95. doi: 10.1111/papr.12100. Epub 2013 Aug 14.
9
Evaluation of patterns and appropriate gastro protection in Albanian primary health care users.评估阿尔巴尼亚初级卫生保健使用者的模式和适当的胃保护。
J Biol Regul Homeost Agents. 2013 Jan-Mar;27(1):247-51.
10
Upper gastrointestinal bleeding associated with NSAIDs, other drugs and interactions: a nested case-control study in a new general practice database.与 NSAIDs、其他药物和相互作用相关的上消化道出血:一项嵌套病例对照研究在新的一般实践数据库中。
Eur J Clin Pharmacol. 2013 Mar;69(3):691-701. doi: 10.1007/s00228-012-1386-3. Epub 2012 Sep 6.

基层医疗保健使用者中的非甾体抗炎药与胃保护

Non-steroidal anti-inflammatory drugs and gastroprotection in primary health care users.

作者信息

Shabani Driton, Murtezani Ardiana, Tahirbegolli Bernard, Juniku-Shkololli Argjira, Ibraimi Zana

机构信息

Department of Pharmacy, Faculty of Medicine, University of Prishtina, Kosovo.

Physical Medicine and Rehabilitation Clinic, University Clinical Center of Kosovo.

出版信息

Med Pharm Rep. 2020 Jul;93(3):246-252. doi: 10.15386/mpr-1533. Epub 2020 Jul 22.

DOI:10.15386/mpr-1533
PMID:32832889
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7418831/
Abstract

OBJECTIVE

The aim of this study is to assess the prevalence of gastroprotection and identify the main factors that influence the taking of protective drugs by the adult population treated with non-steroidal anti-inflammatory drugs (NSAID).

METHODS

This study was cross-sectional, conducted by including a contingent of 800 users of primary health care services (n=369, 46% males and n=431, 54% females). Included in the study were individuals of both genders aged 18+ who sought counselling or treatment during the three-month period. The data collection of this study was based on the completion of a structured questionnaire, which included questions related to the use of NSAIDs, the way these drugs were prescribed and administered and the simultaneous taking of gastroprotective drugs.

RESULTS

The prevalence of the gastroprotective drugs use was higher among the elderly, individuals living in urban areas, those with higher education, those with daily use of NSAID, individuals receiving prescriptions from their own doctors, and those suffering from side effects from the use of NSAID, as well as subjects that had a longer duration of NSAID use. Diclofenac was the most prescribed NSAID. Gastric pain and dizziness were the most experienced side effects.

CONCLUSION

This paper demonstrates the need to improve the quality of primary health care service through informing and educating patients regarding the need to take gastro-protective drugs for those at high risk of adverse effects manifested by the use of NSAIDs.

摘要

目的

本研究旨在评估胃保护措施的普及率,并确定影响使用非甾体抗炎药(NSAID)治疗的成年人群服用保护药物的主要因素。

方法

本研究为横断面研究,纳入了800名初级卫生保健服务使用者(男性369名,占46%;女性431名,占54%)。研究对象为年龄在18岁及以上、在三个月内寻求咨询或治疗的男女个体。本研究的数据收集基于一份结构化问卷的填写,问卷包括与NSAID使用、这些药物的处方和给药方式以及同时服用胃保护药物相关的问题。

结果

在老年人、居住在城市地区的人、受过高等教育的人、每天使用NSAID的人、从自己的医生处获得处方的人、使用NSAID出现副作用的人以及NSAID使用时间较长的人群中,胃保护药物的使用率较高。双氯芬酸是处方最多的NSAID。胃痛和头晕是最常出现的副作用。

结论

本文表明有必要通过告知和教育患者,让其了解对于有使用NSAID出现不良反应高风险的人群服用胃保护药物的必要性,从而提高初级卫生保健服务的质量。