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基层医疗保健使用者中的非甾体抗炎药与胃保护

Non-steroidal anti-inflammatory drugs and gastroprotection in primary health care users.

作者信息

Shabani Driton, Murtezani Ardiana, Tahirbegolli Bernard, Juniku-Shkololli Argjira, Ibraimi Zana

机构信息

Department of Pharmacy, Faculty of Medicine, University of Prishtina, Kosovo.

Physical Medicine and Rehabilitation Clinic, University Clinical Center of Kosovo.

出版信息

Med Pharm Rep. 2020 Jul;93(3):246-252. doi: 10.15386/mpr-1533. Epub 2020 Jul 22.

Abstract

OBJECTIVE

The aim of this study is to assess the prevalence of gastroprotection and identify the main factors that influence the taking of protective drugs by the adult population treated with non-steroidal anti-inflammatory drugs (NSAID).

METHODS

This study was cross-sectional, conducted by including a contingent of 800 users of primary health care services (n=369, 46% males and n=431, 54% females). Included in the study were individuals of both genders aged 18+ who sought counselling or treatment during the three-month period. The data collection of this study was based on the completion of a structured questionnaire, which included questions related to the use of NSAIDs, the way these drugs were prescribed and administered and the simultaneous taking of gastroprotective drugs.

RESULTS

The prevalence of the gastroprotective drugs use was higher among the elderly, individuals living in urban areas, those with higher education, those with daily use of NSAID, individuals receiving prescriptions from their own doctors, and those suffering from side effects from the use of NSAID, as well as subjects that had a longer duration of NSAID use. Diclofenac was the most prescribed NSAID. Gastric pain and dizziness were the most experienced side effects.

CONCLUSION

This paper demonstrates the need to improve the quality of primary health care service through informing and educating patients regarding the need to take gastro-protective drugs for those at high risk of adverse effects manifested by the use of NSAIDs.

摘要

目的

本研究旨在评估胃保护措施的普及率,并确定影响使用非甾体抗炎药(NSAID)治疗的成年人群服用保护药物的主要因素。

方法

本研究为横断面研究,纳入了800名初级卫生保健服务使用者(男性369名,占46%;女性431名,占54%)。研究对象为年龄在18岁及以上、在三个月内寻求咨询或治疗的男女个体。本研究的数据收集基于一份结构化问卷的填写,问卷包括与NSAID使用、这些药物的处方和给药方式以及同时服用胃保护药物相关的问题。

结果

在老年人、居住在城市地区的人、受过高等教育的人、每天使用NSAID的人、从自己的医生处获得处方的人、使用NSAID出现副作用的人以及NSAID使用时间较长的人群中,胃保护药物的使用率较高。双氯芬酸是处方最多的NSAID。胃痛和头晕是最常出现的副作用。

结论

本文表明有必要通过告知和教育患者,让其了解对于有使用NSAID出现不良反应高风险的人群服用胃保护药物的必要性,从而提高初级卫生保健服务的质量。

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