Di Bartolomeo Stefano, Marino Massimiliano, Ventura Chiara, De Palma Rossana
Regional Agency for Health and Social Care of Emilia-Romagna, Viale Aldo Moro 21, 40127 Bologna, Italy; Azienda Ospedaliero-Universitaria di Udine, Italy.
Injury. 2014 Jan;45(1):299-303. doi: 10.1016/j.injury.2013.02.015. Epub 2013 Mar 13.
Trauma Centres (TC) are expected to have a lower mortality - after controlling for injury-severity - than non-designated hospitals in order to justify their funding. This benefit has been demonstrated in the USA not long ago, while the evidence from other settings is still limited. We evaluated the mortality benefit of TC care in an Italian setting, where the first Trauma System with designated TCs was instituted six years ago.
We compared 30-day mortality among 4059 severely injured patients treated in the three TCs and in 12 other hospitals of the region Emilia-Romagna, Italy between 2007 and 2011. We used propensity-score weighting to adjust for differences in potential confounders.
In the overall population there was no difference in the adjusted mortality - OR (95% CI) 1.02 (0.81-1.29). However, an interaction existed between TC care and injury severity. Subgroup analyses showed that the benefit of TC care was significant for the patients with a TMPM-ICD9 severity score>0.12 - OR (95% CI) 0.70 (0.52-0.97). These patients comprised about one-third of the study population. Further subgroup investigations showed that this effect was concentrated in the patients with less than 45 years.
The risk of death for patients with particularly severe injuries is significantly lower when they are treated in TCs as compared to Non-Trauma Centres, especially if they are younger than 45 years. TC care should be provided to a larger number of patients than currently done.
为了证明创伤中心(TC)资金投入的合理性,预期在控制损伤严重程度后,其死亡率应低于非指定医院。不久前美国已证实了这种益处,而其他地区的相关证据仍然有限。我们评估了在意大利环境下创伤中心治疗的死亡率益处,该国六年前建立了首个设有指定创伤中心的创伤系统。
我们比较了2007年至2011年间在意大利艾米利亚 - 罗马涅地区的三家创伤中心和其他12家医院接受治疗的4059名重伤患者的30天死亡率。我们使用倾向得分加权来调整潜在混杂因素的差异。
在总体人群中,调整后的死亡率没有差异 - 比值比(95%置信区间)为1.02(0.81 - 1.29)。然而,创伤中心治疗与损伤严重程度之间存在相互作用。亚组分析表明,对于创伤和损伤严重程度指数 - 国际疾病分类第九版(TMPM - ICD9)严重程度评分>0.12的患者,创伤中心治疗的益处显著 - 比值比(95%置信区间)为0.70(0.52 - 0.97)。这些患者约占研究人群的三分之一。进一步的亚组调查表明,这种效应集中在年龄小于45岁的患者中。
与非创伤中心相比,重伤患者在创伤中心接受治疗时死亡风险显著降低,尤其是年龄小于45岁的患者。应向比目前更多的患者提供创伤中心治疗。