全反式维甲酸在中国治疗急性早幼粒细胞白血病的应用
Treatment of acute promyelocytic leukemia with all-trans retinoic acid in China.
作者信息
Wang Z Y, Sun G L, Lu J X, Gu L J, Huang M E, Chen S R
机构信息
Shanghai Institute of Hematology, Shanghai Second Medical University, China.
出版信息
Nouv Rev Fr Hematol (1978). 1990;32(1):34-6.
Seventy patients with acute promyelocytic leukemia (APL) were entered in this study. Fifty-seven cases received all-trans retinoic acid (RA) as sole agent and 48 cases (84.2%) attained complete remission (CR) in about 42 days. While the other 8 cases (14%) obtained partial remission (PR) during some time. Thirteen patients received combinations of RA and chemotherapy. 9 cases (69.2%) attained CR in about two months and 4 other cases (30.8%) got PR. Total CR rate reached 95.9% after continuing the treatment. Fifty cases were closely followed after CR. Three kinds of continuation therapy were administered including RA as sole agent (Group A), chemotherapy alone (Group B) and RA and chemotherapy alternatively (Group C). The results showed Group C gave the longest duration of CR and longest duration of survival.
70例急性早幼粒细胞白血病（APL）患者进入本研究。57例患者接受全反式维甲酸（RA）作为单一药物治疗，48例（84.2%）在约42天内达到完全缓解（CR）。另外8例（14%）在一段时间内获得部分缓解（PR）。13例患者接受了RA与化疗的联合治疗。9例（69.2%）在约两个月内达到CR，另外4例（30.8%）获得PR。继续治疗后总CR率达到95.9%。50例患者在CR后进行密切随访。采用了三种维持治疗方法，包括以RA作为单一药物（A组）、单纯化疗（B组）以及RA与化疗交替使用（C组）。结果显示，C组的CR持续时间最长，生存时间也最长。
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