Proctor R A, White J D, Ayala E, Canonico P G
Infect Immun. 1975 Jan;11(1):146-51. doi: 10.1128/iai.11.1.146-151.1975.
Phagocytosis of Francisella tularensis by rhesus monkey peripheral neutrophils (PMN, was assessed by autoradiography, electron microscopy, and biochemical techniques. PMN, in contrast to mononuclear phagocytes, were unable to phagocytize F. tularensis in vitro in the absence of immune serum. It is postulated that in the nonimmune host the innate inability of PMN to phagocytize F. tularensis deletes one of the possible mechanisms of host defense to bacterial infection and thus permits the early dissemination of F. tularensis to intracellular sites of specific target tissues.
通过放射自显影、电子显微镜和生化技术评估了恒河猴外周血中性粒细胞（PMN）对土拉弗朗西斯菌的吞噬作用。与单核吞噬细胞不同，在没有免疫血清的情况下，PMN在体外无法吞噬土拉弗朗西斯菌。据推测，在非免疫宿主中，PMN天生无法吞噬土拉弗朗西斯菌，这消除了宿主防御细菌感染的一种可能机制，从而使土拉弗朗西斯菌能够早期扩散到特定靶组织的细胞内部位。
