[豚鼠及免疫土拉菌病的豚鼠吞噬杀菌系统的活性]

[The activity of the phagocytic bactericidal systems in intact guinea pigs and in guinea pigs immunized against tularemia].

作者信息

Golubinskiĭ E P, Boĭkova I S, Dubrovina V I

出版信息

Zh Mikrobiol Epidemiol Immunobiol. 1995 Mar-Apr(2):77-9.

Abstract

The activities of NADP-oxidase and glucose-6-phosphate dehydrogenase in mononuclear phagocytes and polymorphonuclear leukocytes (PML) during the phagocytosis of Francisella tularensis and the influence of immunization of on the activity of oxygen-dependent metabolism were studied. The phagocytosis of F.tularensis was found to be accompanied by a rise in the activity of NADP.H-oxidase and glucose-6-phosphate dehydrogenase. In the process of immunogenesis the rearrangement of the enzymatic system ensuring the antimicrobial action of phagocytes occurred. Macrophages exhibited higher enzymatic activity than PML.

摘要

研究了土拉弗朗西斯菌吞噬过程中单核吞噬细胞和多形核白细胞（PML）中NADP氧化酶和葡萄糖-6-磷酸脱氢酶的活性，以及免疫对氧依赖性代谢活性的影响。发现土拉弗朗西斯菌的吞噬作用伴随着NADP.H氧化酶和葡萄糖-6-磷酸脱氢酶活性的升高。在免疫发生过程中，确保吞噬细胞抗菌作用的酶系统发生了重排。巨噬细胞表现出比PML更高的酶活性。