Boggild M D, Peck R W, Tomson C R
Department of Medicine, Leicester Royal Infirmary, UK.
Postgrad Med J. 1990 Jan;66(771):40-1. doi: 10.1136/pgmj.66.771.40.
A fatal case of acetonitrile ingestion is reported. The patient presented having apparently taken an overdose but was well until around 24 hours after the supposed ingestion, when cardiovascular collapse and profound metabolic acidosis developed. Later investigation revealed that the patient had taken acetone and acetonitrile. Acetone is known to slow the metabolism of acetonitrile to cyanide, thereby delaying the appearance of toxicity.
报告了一例乙腈摄入致死的病例。患者就诊时显然服用了过量药物，但在假定摄入药物约24小时前情况良好，之后出现心血管衰竭和严重代谢性酸中毒。后续调查显示患者摄入了丙酮和乙腈。已知丙酮会减缓乙腈向氰化物的代谢，从而延迟毒性的显现。
