Mueller M, Borland C
Hinchingbrooke Hospital, Huntingdon, Cambridgeshire, UK.
Postgrad Med J. 1997 May;73(859):299-300. doi: 10.1136/pgmj.73.859.299.
Acetonitrile (methyl cyanide) is a common industrial organic solvent but is a rare cause of poisoning. We report the first recorded UK case. Acetonitrile is slowly converted to cyanide, resulting in delayed toxicity. We describe a case of deliberate self-poisoning by a 39-year-old woman resulting in cyanide poisoning 11 hours later which was successfully treated by repeated boluses of sodium nitrite and thiosulphate. The half-life of conversion of acetonitrile was 40 hours and harmful blood cyanide levels persisted for over 24 hours after ingestion. Departments treating or advising in cases of poisoning need to be aware of the delayed toxicity of acetonitrile. Monitoring in an intensive care unit of cases of acetonitrile poisoning should continue for 24-48 hours.
乙腈（甲基氰）是一种常见的工业有机溶剂，但中毒情况较为罕见。我们报告英国首例有记录的病例。乙腈会缓慢转化为氰化物，导致延迟性中毒。我们描述了一名39岁女性蓄意自我中毒的病例，11小时后导致氰化物中毒，通过反复推注亚硝酸钠和硫代硫酸钠成功治愈。乙腈转化的半衰期为40小时，摄入后有害血氰水平持续超过24小时。治疗中毒病例或提供咨询的科室需要了解乙腈的延迟性毒性。对乙腈中毒病例在重症监护病房的监测应持续24至48小时。
