Fos M, Domínguez M A, Latorre A, Moya A
Departamento de Genética, Facultad de Biología, Universitat de Valencia, Spain.
Proc Natl Acad Sci U S A. 1990 Jun;87(11):4198-201. doi: 10.1073/pnas.87.11.4198.
When two mitochondrial DNA (mtDNA) haplotypes of Drosophila subobscura compete in experimental populations with discrete generations, one or the other approaches fixation, depending on the nuclear background with which they are associated. The approach to fixation, however, is strongly dependent on the effective number of females in the population, Nf. Whether or not the ultimate fate of a given mtDNA haplotype is determined by random genetic drift depends on Nf as well as on the relative fitnesses. Our experimental results show that the mtDNA polymorphisms observed in natural populations are affected by interactions among nuclear polymorphisms, random genetic drift, and direct selection on the mtDNA haplotypes.
当两种果蝇的线粒体DNA（mtDNA）单倍型在具有离散世代的实验种群中竞争时，其中一种或另一种会趋于固定，这取决于它们所关联的核背景。然而，趋于固定的过程强烈依赖于种群中雌性的有效数量Nf。给定mtDNA单倍型的最终命运是否由随机遗传漂变决定，既取决于Nf，也取决于相对适合度。我们的实验结果表明，在自然种群中观察到的mtDNA多态性受到核多态性、随机遗传漂变以及对mtDNA单倍型的直接选择之间相互作用的影响。
