Akagi H, Ochi H, Kannno N, Iwata M, Ichinohe T, Harada Y, Nezu Y, Yogo T, Tagawa M, Hara Y
Division of Veterinary Surgery, Department of Veterinary Science, Faculty of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan.
Vet Comp Orthop Traumatol. 2013;26(2):123-9. doi: 10.3415/VCOT-11-12-0186.
To evaluate the efficacy of cortical allograft and fibroblast growth factor 2 (FGF-2)-impregnated autogenous cancellous bone in nonunion fracture repair in dogs.
From January 2000 to August 2010, seven dogs underwent cortical allograft and FGF-2-impregnated autogenous cancellous bone implantation for treatment of a femoral nonunion following fracture. Radiographic images were used to assess healing.
The average length of the implanted cortical allograft was 29.1 ± 4.4 mm. A significant improvement in the postoperative percentage of femoral shortening was observed with the experimental treatment, from 85.2 ± 8.2% to 95.0 ± 4.8%. Using radiographic scoring, we analysed the process of bone remodelling. At three months post-surgery, the proximal and distal fracture lines had begun to disappear, and a complete absence was observed after six months. Bacterial infection was detected in two of the seven cases.
The findings of our study suggest that the combination of cortical allografts with FGF-2 impregnated cancellous autograft may be useful in cases of diaphyseal fracture non-union. The disappearance of the fracture line in dogs with nonunion was recognized at the same phase as the report in which healing process of allograft was evaluated in the experimental ostectomy model using the normal dog.
评估同种异体皮质骨和含成纤维细胞生长因子2（FGF-2）的自体松质骨在犬骨折不愈合修复中的疗效。
2000年1月至2010年8月，7只犬接受同种异体皮质骨和含FGF-2的自体松质骨植入术，以治疗股骨骨折不愈合。采用X线影像评估愈合情况。
植入的同种异体皮质骨平均长度为29.1±4.4毫米。实验治疗后，股骨缩短的术后百分比有显著改善，从85.2±8.2%降至95.0±4.8%。我们使用X线评分分析了骨重塑过程。术后3个月，近端和远端骨折线开始消失，6个月后完全消失。7例中有2例检测到细菌感染。
我们的研究结果表明，同种异体皮质骨与含FGF-2的松质骨自体移植相结合可能对骨干骨折不愈合病例有用。骨折不愈合犬的骨折线消失阶段与在正常犬实验性截骨模型中评估同种异体移植愈合过程的报告相同。
