Kerwin S C, Lewis D D, Elkins A D, Oliver J, Pechman R, McCarthy R J, Hosgood G
Department of Veterinary Clinical Science, School of Veterinary Medicine, Louisiana State University, Baton Rouge, USA.
Vet Surg. 1996 Jan-Feb;25(1):18-28. doi: 10.1111/j.1532-950x.1996.tb01373.x.
Deep-frozen, aseptically collected and processed allogeneic cancellous bone was implanted in eight dogs during the surgical repair of diaphyseal long bone fractures and in two dogs during arthrodeses. A combined allogeneic and autogeneic cancellous bone graft was used in two fractures with a segmental bone loss of more than 5 cm. Bone union occurred in five fractures and in both arthrodeses. Failure of fixation occurred in two dogs with nonunion fractures and in a third dog with an open, infected fracture. Biopsies from the fracture sites were obtained from these dogs following failure of their fracture fixation. The cancellous bone graft appeared to be in the process of normal incorporation in each case. Failure of fixation was attributed to technical or case management errors or both, in each of the three fractures that failed to achieve bony union. Frozen allogeneic cancellous bone grafts were effectively incorporated when used in the primary repair of fractures and arthrodeses. Combined autogenous and allogeneic cancellous bone grafts may be particularly useful in the repair of fractures with large segmental diaphyseal bone defects. The use of allogeneic cancellous bone grafts in nonunion fractures requires further investigation before it can be recommended.
在8只犬的骨干长骨骨折手术修复过程中以及2只犬的关节固定术中植入了经深冻、无菌采集和处理的同种异体松质骨。在2例骨干骨缺损超过5 cm的骨折中使用了同种异体和自体松质骨联合移植。5例骨折和2例关节固定均实现了骨愈合。2例骨折不愈合的犬和第3例开放性感染骨折的犬出现了内固定失败。在这些犬的骨折内固定失败后，从骨折部位取了活检样本。在每例中，松质骨移植似乎都处于正常整合过程中。在3例未实现骨愈合的骨折中，内固定失败均归因于技术或病例管理失误或两者兼有。冷冻同种异体松质骨移植用于骨折和关节固定的一期修复时能有效整合。自体和同种异体松质骨联合移植可能对伴有大段骨干骨缺损的骨折修复特别有用。在不愈合骨折中使用同种异体松质骨移植在能够推荐之前还需要进一步研究。
