Rheumatology/Immunology/Allergy, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China.
Phytother Res. 2013 Dec;27(12):1863-7. doi: 10.1002/ptr.4933. Epub 2013 Mar 11.
Ascorbigen (ABG) is the predominant indole-derived compound from Brassica vegetables. In this study, we attempted to evaluate the effects of ABG on hair growth. To this end, we examined the proliferation of isolated human dermal papilla (DP) cells and keratinocytes after incubation in various concentrations (0-1.25 mM) of ABG. Furthermore, hair shaft regrowth was monitored in a mouse model of chemotherapy-induced alopecia (CIA), and hematoxylin and eosin staining was performed for histological analyses. We found that 1.25 mM ABG induced a 1.2-fold increase in the growth of DP cells, but not keratinocytes. However, ABG did not exert significant protective effects against CIA in the mouse model. These findings suggest that ABG may not be able to counteract CIA and that further investigation of the therapeutic potential of ABG in disease models is required.
抗坏血酸葡萄糖苷（ABG）是蔬菜中主要的吲哚衍生化合物。在这项研究中，我们试图评估 ABG 对毛发生长的影响。为此，我们检测了不同浓度（0-1.25mM）ABG 孵育后分离的人真皮乳头（DP）细胞和角质形成细胞的增殖情况。此外，我们还在化疗诱导脱发（CIA）的小鼠模型中监测了毛干的再生，并进行了苏木精和伊红染色进行组织学分析。结果发现，1.25mM 的 ABG 可使 DP 细胞的生长增加 1.2 倍，但对角质形成细胞没有明显的影响。然而，ABG 并没有在 CIA 小鼠模型中发挥显著的保护作用。这些结果表明，ABG 可能无法对抗 CIA，需要在疾病模型中进一步研究 ABG 的治疗潜力。
