“点击式”水溶型聚乙二醇化隐色 cryptophane 作为 129Xe 磁共振成像生物传感器的通用平台。
"Clickable" hydrosoluble PEGylated cryptophane as a universal platform for 129Xe magnetic resonance imaging biosensors.
机构信息
iBiTecS, Service de Chimie Bioorganique et de Marquage (SCBM), CEA, 91191 Gif-sur-Yvette, France.
出版信息
Chemistry. 2013 May 3;19(19):6089-93. doi: 10.1002/chem.201204218. Epub 2013 Mar 13.
PMID:23494947
Abstract
We describe the synthesis of a highly water-soluble cryptophane 1 that can be seen as a universal platform for the construction of (129)Xe magnetic resonance imaging (MRI)-based biosensors. Compound 1 is easily functionalized by Huisgen cycloaddition and exhibits excellent xenon-encapsulation properties. In addition, 1 is nontoxic at the concentrations typically used for hyperpolarized (129)Xe MRI.
摘要
我们描述了一种高水溶性隐色 cryptophane 1 的合成，它可以被视为构建基于 (129)Xe 磁共振成像（MRI）的生物传感器的通用平台。化合物 1 很容易通过 Huisgen 环加成进行功能化，并表现出优异的氙气封装性能。此外，在通常用于超极化 (129)Xe MRI 的浓度下，1 是无毒的。
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