通过基于 Fe(II)-联吡啶配合物的动态组合文库实现碳水化合物-蛋白质识别的动态多价性。
Dynamic multivalency for carbohydrate-protein recognition through dynamic combinatorial libraries based on Fe(II)-bipyridine complexes.
机构信息
The Institute of Chemical Research of Catalonia (ICIQ), Avda. Països Catalans 16, 43007-Tarragona, Spain.
出版信息
Chemistry. 2013 Apr 22;19(17):5259-62. doi: 10.1002/chem.201300464. Epub 2013 Mar 11.
PMID:23495220
Abstract
Molecular recognition: Dynamic combinatorial libraries (DCLs) exploiting multivalency effects and metal coordination have been employed for carbohydrate-protein recognition. The interaction of a three-component DCL based on 2,2'-bipyridine (bipy)-Fe(II) complexes with concanavalin A (ConA; see scheme) results in enhanced binding by multivalent presentation with a bias towards mannose-containing library components.
摘要
分子识别
利用多价效应和金属配位的动态组合库 (DCL) 已被用于碳水化合物-蛋白质识别。基于 2,2'-联吡啶 (bipy)-Fe(II) 配合物的三组分 DCL 与伴刀豆球蛋白 A (ConA；见方案) 的相互作用通过多价呈现增强结合，偏向于含甘露糖的库成分。
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