1,5-二硫代氨基甲酰基双糖四价构建物的合成与评价。
Synthesis and evaluation of 1,5-dithialaminaribiose and -triose tetravalent constructs.
机构信息
Department of Chemistry, University of Georgia, 302 East Campus Road, Athens, GA, 30602, United States; Department of Pharmaceutical and Biomedical Sciences, University of Georgia, 250 West Green Street, Athens, GA, 30602, United States.
Department of Pharmaceutical and Biomedical Sciences, University of Georgia, 250 West Green Street, Athens, GA, 30602, United States.
出版信息
Carbohydr Res. 2023 Mar;525:108781. doi: 10.1016/j.carres.2023.108781. Epub 2023 Mar 2.
Abstract
We report the synthesis of novel tetravalent glucoclusters containing 1,5-dithia mimetics of laminaribiose and triose. The new constructs were evaluated for their ability to inhibit anti-CR3 fluorescent staining of human neutrophils, for which they showed moderate affinity. Evaluation of the synthesized glycoclusters for their ability to inhibit anti-Dectin-1 fluorescent staining of mouse macrophages revealed little to no affinity for Dectin-1.
摘要
我们报告了含有 1,5-二硫代戊糖类似物和丙三糖的新型四价葡糖簇的合成。评估了新构建体抑制人中性粒细胞抗 CR3 荧光染色的能力，它们表现出中等亲和力。评估合成的糖簇抑制小鼠巨噬细胞抗 Dectin-1 荧光染色的能力，发现对 Dectin-1 的亲和力很小或没有。
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