预测华法林每日凝血酶原时间反应。
Predicting the daily prothrombin time response to warfarin.
作者信息
Farrow L, Mungall D, Raskob G, Hull R
机构信息
Department of Pharmacy, Ingham Medical Center, Lansing, Michigan.
出版信息
Ther Drug Monit. 1990 May;12(3):246-9. doi: 10.1097/00007691-199005000-00006.
Our objective was to evaluate the effectiveness of a computer program to predict daily prothrombin time (PT) response to warfarin therapy using prospectively collected data. The program's predictive performance (precision) and accuracy (bias) were evaluated using fraction mean absolute error and fraction mean error, respectively. We analyzed data from 40 patients using from zero to nine PT feedbacks. The fraction mean absolute error varied from 0.058 to 0.13. The program utilized a pharmacokinetic/pharmacodynamic Bayesian forecasting system to predict prothrombin response.
我们的目标是使用前瞻性收集的数据评估一个计算机程序预测华法林治疗每日凝血酶原时间（PT）反应的有效性。分别使用分数平均绝对误差和分数平均误差评估该程序的预测性能（精度）和准确性（偏差）。我们分析了40例患者的数据，这些患者有0至9次PT反馈。分数平均绝对误差在0.058至0.13之间变化。该程序利用药代动力学/药效学贝叶斯预测系统来预测凝血酶原反应。
Zotero 插件