肠道微生物群、益生菌与心理健康：从梅契尼科夫到现代进展：第二部分——当代背景研究。
Intestinal microbiota, probiotics and mental health: from Metchnikoff to modern advances: Part II - contemporary contextual research.
机构信息
CAMNR, 775 Blithedale Avenue, Suite 364, Mill Valley, CA 94941, USA.
出版信息
Gut Pathog. 2013 Mar 14;5(1):3. doi: 10.1186/1757-4749-5-3.
Abstract
In recent years there has been a renewed interest concerning the ways in which the gastrointestinal tract - its functional integrity and microbial residents - might influence human mood (e.g. depression) and behavioral disorders. Once a hotbed of scientific interest in the early 20th century, this area lay dormant for decades, in part due to its association with the controversial term 'autointoxication'. Here we review contemporary findings related to intestinal permeability, small intestinal bacterial overgrowth, lipopolysaccharide endotoxin (LPS) exposure, D-lactic acid, propionic acid, and discuss their relevance to microbiota and mental health. In addition, we include the context of modern dietary habits as they relate to depression, anxiety and their potential interaction with intestinal microbiota.
摘要
近年来，人们重新关注胃肠道（其功能完整性和微生物居民）可能影响人类情绪（例如抑郁）和行为障碍的方式。这个领域在 20 世纪早期曾是科学研究的热点，但在几十年里一直处于休眠状态，部分原因是它与有争议的术语“自体中毒”有关。在这里，我们回顾了与肠道通透性、小肠细菌过度生长、脂多糖内毒素 (LPS) 暴露、D-乳酸、丙酸相关的当代发现，并讨论了它们与微生物组和心理健康的关系。此外，我们还包括了现代饮食习惯与抑郁、焦虑及其与肠道微生物群相互作用的相关内容。
相似文献
1
Intestinal microbiota, probiotics and mental health: from Metchnikoff to modern advances: Part II - contemporary contextual research.肠道微生物群、益生菌与心理健康：从梅契尼科夫到现代进展：第二部分——当代背景研究。
Gut Pathog. 2013 Mar 14;5(1):3. doi: 10.1186/1757-4749-5-3.
2
Intestinal microbiota, probiotics and mental health: from Metchnikoff to modern advances: Part I - autointoxication revisited.肠道微生物群、益生菌与心理健康：从梅契尼科夫到现代进展：第一部分——重新审视自体中毒。
Gut Pathog. 2013 Mar 18;5(1):5. doi: 10.1186/1757-4749-5-5.
3
Intestinal microbiota, probiotics and mental health: from Metchnikoff to modern advances: part III - convergence toward clinical trials.肠道微生物群、益生菌与心理健康：从梅契尼科夫到现代进展：第三部分——向临床试验趋同。
Gut Pathog. 2013 Mar 16;5(1):4. doi: 10.1186/1757-4749-5-4.
4
Natural environments, ancestral diets, and microbial ecology: is there a modern "paleo-deficit disorder"? Part II.自然环境、祖传饮食与微生物生态学：是否存在现代“古式营养缺乏症”？第二部分。
J Physiol Anthropol. 2015 Mar 10;34(1):9. doi: 10.1186/s40101-014-0040-4.
5
A review of dietary and microbial connections to depression, anxiety, and stress.饮食与微生物与抑郁、焦虑和压力的关系综述。
Nutr Neurosci. 2020 Mar;23(3):237-250. doi: 10.1080/1028415X.2018.1493808. Epub 2018 Jul 9.
6
Immunology and probiotic impact of the newborn and young children intestinal microflora.新生儿和幼儿肠道微生物菌群的免疫学和益生菌影响。
Anaerobe. 2011 Dec;17(6):369-74. doi: 10.1016/j.anaerobe.2011.03.010. Epub 2011 Apr 16.
7
Acne vulgaris, probiotics and the gut-brain-skin axis: from anecdote to translational medicine.寻常痤疮、益生菌与肠-脑-皮肤轴：从趣闻到转化医学
Benef Microbes. 2014 Jun 1;5(2):185-99. doi: 10.3920/BM2012.0060.
8
Probiotics supplementation in prophylaxis and treatment of depressive and anxiety disorders - a review of current research.补充益生菌预防和治疗抑郁及焦虑障碍——当前研究综述
Psychiatr Pol. 2019 Apr 30;53(2):459-473. doi: 10.12740/PP/92392.
9
Could the beneficial effects of dietary calcium on obesity and diabetes control be mediated by changes in intestinal microbiota and integrity?膳食钙对肥胖和糖尿病控制的有益作用是否可通过肠道微生物群及其完整性的变化来介导？
Br J Nutr. 2015 Dec 14;114(11):1756-65. doi: 10.1017/S0007114515003608. Epub 2015 Sep 24.
10
Are Probiotics Effective in Targeting Alcoholic Liver Diseases?益生菌在靶向治疗酒精性肝病方面有效吗？
Probiotics Antimicrob Proteins. 2019 Jun;11(2):335-347. doi: 10.1007/s12602-018-9419-6.
引用本文的文献
1
The Pathogenesis and Medical Treatment of Depression: Opportunity and Challenge.抑郁症的发病机制与医学治疗：机遇与挑战
Neurol Int. 2025 Aug 4;17(8):120. doi: 10.3390/neurolint17080120.
2
Assessment of the Gut Microbiome in Patients with Coexisting Irritable Bowel Syndrome and Chronic Fatigue Syndrome.肠易激综合征与慢性疲劳综合征并存患者的肠道微生物群评估
Nutrients. 2025 Jul 5;17(13):2232. doi: 10.3390/nu17132232.
3
Being a better version of yourself: genetically engineered probiotic bacteria as host defense enhancers in the control of intestinal pathogens.成为更好的自己：基因工程益生菌作为宿主防御增强剂用于控制肠道病原体
Gut Microbes. 2025 Dec;17(1):2519696. doi: 10.1080/19490976.2025.2519696. Epub 2025 Jun 18.
4
Antioxidant and Anti-Inflammatory Effects of Bioactive Compounds in Atherosclerosis.生物活性化合物在动脉粥样硬化中的抗氧化和抗炎作用
Int J Mol Sci. 2025 Feb 6;26(3):1379. doi: 10.3390/ijms26031379.
5
Effects of fermentation conditions (salt concentration, temperature, and pH) on Lactobacillus strains for induction of interleukin-12 in the exposed murine splenocytes.发酵条件（盐浓度、温度和pH值）对暴露的小鼠脾细胞中诱导白细胞介素-12的乳酸杆菌菌株的影响。
Heliyon. 2024 Oct 26;10(22):e39837. doi: 10.1016/j.heliyon.2024.e39837. eCollection 2024 Nov 30.
6
Adjuvant administration of probiotic effects on sexual function in depressant women undergoing SSRIs treatment: a double-blinded randomized controlled trial.辅助给予益生菌对接受 SSRIs 治疗的抑郁女性性功能的影响：一项双盲随机对照试验。
BMC Psychiatry. 2024 Jan 12;24(1):44. doi: 10.1186/s12888-023-05429-w.
7
Probiotics Improve Vaginal Dysbiosis in Asymptomatic Women.益生菌可改善无症状女性的阴道菌群失调。
Nutrients. 2023 Apr 13;15(8):1862. doi: 10.3390/nu15081862.
8
Microarray analysis reveals the potential molecular mechanism of Lp299v in stable coronary atherosclerotic disease.基因芯片分析揭示了Lp299v在稳定型冠状动脉粥样硬化疾病中的潜在分子机制。
AMB Express. 2022 Sep 24;12(1):125. doi: 10.1186/s13568-022-01466-y.
9
Secondary Dysfunction of the Intestinal Barrier in the Pathogenesis of Complications of Acute Poisoning.急性中毒并发症发病机制中肠屏障的继发性功能障碍
J Evol Biochem Physiol. 2022;58(4):1075-1098. doi: 10.1134/S0022093022040123. Epub 2022 Aug 28.
10
The Gut Microbiome in Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS).肌痛性脑脊髓炎/慢性疲劳综合征（ME/CFS）中的肠道微生物组。
Front Immunol. 2022 Jan 3;12:628741. doi: 10.3389/fimmu.2021.628741. eCollection 2021.
本文引用的文献
1
Gestational and lactational exposure to bisphenol-A affects anxiety- and depression-like behaviors in mice.孕期和哺乳期接触双酚 A 会影响小鼠的焦虑和抑郁样行为。
Horm Behav. 2012 Sep;62(4):480-90. doi: 10.1016/j.yhbeh.2012.08.005.
2
Dietary intake of magnesium may modulate depression.镁的膳食摄入量可能会调节抑郁症。
Biol Trace Elem Res. 2013 Mar;151(3):324-9. doi: 10.1007/s12011-012-9568-5. Epub 2012 Dec 14.
3
The microbiota is essential for the generation of black tea theaflavins-derived metabolites.微生物群对于生成红茶茶黄素衍生代谢物至关重要。
PLoS One. 2012;7(12):e51001. doi: 10.1371/journal.pone.0051001. Epub 2012 Dec 5.
4
Dysregulated relationship of inflammation and oxidative stress in major depression.在重度抑郁症中，炎症和氧化应激的失调关系。
Brain Behav Immun. 2013 Jul;31:143-52. doi: 10.1016/j.bbi.2012.11.011. Epub 2012 Nov 29.
5
Green tea powder and Lactobacillus plantarum affect gut microbiota, lipid metabolism and inflammation in high-fat fed C57BL/6J mice.绿茶粉和植物乳杆菌影响高脂肪喂养 C57BL/6J 小鼠的肠道微生物群、脂质代谢和炎症。
Nutr Metab (Lond). 2012 Nov 26;9(1):105. doi: 10.1186/1743-7075-9-105.
6
Antidepressant-like effect of trans-resveratrol in chronic stress model: behavioral and neurochemical evidences.反式白藜芦醇在慢性应激模型中的抗抑郁样作用：行为和神经化学证据。
J Psychiatr Res. 2013 Mar;47(3):315-22. doi: 10.1016/j.jpsychires.2012.10.018. Epub 2012 Nov 19.
7
Dietary Factors: Major Regulators of the Gut's Microbiota.饮食因素：肠道微生物群的主要调节因子。
Gut Liver. 2012 Oct;6(4):411-6. doi: 10.5009/gnl.2012.6.4.411. Epub 2012 Aug 7.
8
Bupropion pre-treatment of endotoxin-induced depressive symptoms.丁螺环酮预处理内毒素诱导的抑郁症状。
Brain Behav Immun. 2013 Jul;31:197-204. doi: 10.1016/j.bbi.2012.10.008. Epub 2012 Oct 12.
9
Multiple antidepressant potential modes of action of curcumin: a review of its anti-inflammatory, monoaminergic, antioxidant, immune-modulating and neuroprotective effects.姜黄素的多种抗抑郁作用机制：抗炎、单胺能、抗氧化、免疫调节和神经保护作用的综述。
J Psychopharmacol. 2012 Dec;26(12):1512-24. doi: 10.1177/0269881112458732. Epub 2012 Oct 3.
10
A metagenome-wide association study of gut microbiota in type 2 diabetes.2 型糖尿病患者肠道微生物组的宏基因组关联研究。
Nature. 2012 Oct 4;490(7418):55-60. doi: 10.1038/nature11450. Epub 2012 Sep 26.
Zotero 插件