Mazzone Stuart B, McGovern Alice E, Yang Seung-Kwon, Woo Ariel, Phipps Simon, Ando Ayaka, Leech Jennifer, Farrell Michael J
School of Biomedical Sciences, University of Queensland, St Lucia, Brisbane, QLD, 4072, Australia.
Cough. 2013 Mar 6;9(1):7. doi: 10.1186/1745-9974-9-7.
There is an overwhelming body of evidence to support the existence of higher brain circuitries involved in the sensory detection of airways irritation and the motor control of coughing. The concept that cough is purely a reflex response to airways irritation is now superseded by the recognition that perception of an urge-to-cough and altered behavioral modification of coughing are key elements of cough disorders associated with airways disease. Understanding the pathways by which airway sensory nerves ascend into the brain and the patterns of neural activation associated with airways irritation will undoubtedly provide new insights into disordered coughing. This brief review aims to explore our current understanding of higher order cough networks by summarizing data from recent neuroanatomical and functional studies in animals and humans. We provide evidence for the existence of distinct higher order network components involved in the discrimination of signals arising from the airways and the motor control of coughing. The identification of these network components provides a blueprint for future research and the development of targeted managements for cough and the urge-to-cough.
有大量证据支持存在参与气道刺激感觉检测和咳嗽运动控制的高级脑回路。咳嗽纯粹是对气道刺激的反射反应这一概念，现在已被认识到咳嗽冲动的感知和咳嗽行为改变是气道疾病相关咳嗽障碍的关键要素所取代。了解气道感觉神经升入大脑的途径以及与气道刺激相关的神经激活模式，无疑将为咳嗽紊乱提供新的见解。这篇简短综述旨在通过总结近期动物和人体神经解剖学及功能研究的数据，探讨我们目前对高级咳嗽网络的理解。我们提供证据表明存在不同的高级网络组件，它们参与气道信号的辨别和咳嗽的运动控制。这些网络组件的识别为未来研究以及咳嗽和咳嗽冲动的靶向管理开发提供了蓝图。
