Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College London, Du Cane Road, London W12 0NN, UK.
Cell. 2013 Mar 14;152(6):1285-97. doi: 10.1016/j.cell.2013.02.029.
Current epigenomics approaches have facilitated the genome-wide identification of regulatory elements based on chromatin features and transcriptional regulator binding and have begun to map long-range interactions between regulatory elements and their targets. Here, we focus on the emerging roles of CTCF and the cohesin in coordinating long-range interactions between regulatory elements. We discuss how species-specific transposable elements may influence such interactions by remodeling the CTCF binding repertoire and suggest that cohesin's association with enhancers, promoters, and sites defined by CTCF binding has the potential to form developmentally regulated networks of long-range interactions that reflect and promote cell-type-specific transcriptional programs.
目前的表观基因组学方法已经能够基于染色质特征和转录因子结合来实现调控元件的全基因组鉴定，并开始绘制调控元件与其靶基因之间的长距离相互作用图谱。在这里，我们重点介绍 CTCF 和黏合蛋白在协调调控元件之间的长距离相互作用方面的新作用。我们讨论了物种特异性转座元件如何通过重塑 CTCF 结合谱来影响这种相互作用，并提出黏合蛋白与增强子、启动子和 CTCF 结合定义的位点的关联有可能形成反映和促进细胞类型特异性转录程序的发育调控的长距离相互作用网络。
