Zeeneldin Ahmed Abdelmabood, Ramadan Mohamed, Gaber Ayman Abdelsamee, Taha Fatma Mohamed
Medical Oncology/Hematology, National Cancer Institute, Cairo University, Egypt.
J Egypt Natl Canc Inst. 2013 Mar;25(1):5-11. doi: 10.1016/j.jnci.2012.10.003. Epub 2012 Nov 22.
Breast cancer (BC) is a major worldwide health care problem that mostly afflicts the elderly population in the more developed countries. It is not known how common is breast cancer among elderly Egyptian patients and whether this differs from the disease in younger patients.
To study the clinico-pathological features of BC in elderly Egyptian patients (⩾65years of age) among the population of an Egyptian Governorate, Gharbiah, and to compare these features with those of younger patients (<65years).
This is a cross sectional study that compares elderly BC (EBC) and the non-elderly BC (NEBC) using the information from the Gharbiah Population-based Cancer registry (GPCR) during the years 1999-2007.
Out of 6078 BCs, 12% were EBCs and 88% were NEBCs. Between 1999 and 2007, the crude incidence rate (CIR, per 100,000 populations) of EBC increased from 47 to 71 and that of NEBC increased from 16 to 17. Compared to NEBC patients, EBC patients were more likely to have a positive family history and present with a distant disease and less likely to present with a localized disease. EBCs were more likely to have lung metastases and less likely to have liver metastases. Histology, grade, hormone and HER-2 receptor statuses were comparable in both groups. Apart from hormonal therapies, the elderly were less likely to receive surgery, radiotherapy or chemotherapy.
EBC patients in Egypt present with advanced disease and are less likely to receive surgery, radiotherapy or chemotherapy compared to NEBC patients.
乳腺癌是一个全球性的主要医疗保健问题，在较发达国家主要影响老年人群。目前尚不清楚乳腺癌在埃及老年患者中有多常见，以及与年轻患者的疾病情况是否存在差异。
研究埃及盖勒尤卜省老年患者（年龄≥65岁）中乳腺癌的临床病理特征，并将这些特征与年轻患者（年龄<65岁）的特征进行比较。
这是一项横断面研究，利用1999 - 2007年盖勒尤卜省基于人群的癌症登记处（GPCR）的信息，对老年乳腺癌（EBC）和非老年乳腺癌（NEBC）进行比较。
在6078例乳腺癌中，12%为EBC，88%为NEBC。1999年至2007年期间，EBC的粗发病率（每10万人口）从47增至71，NEBC的粗发病率从16增至17。与NEBC患者相比，EBC患者更有可能有阳性家族史且表现为远处疾病，而表现为局限性疾病的可能性较小。EBC更有可能发生肺转移，而发生肝转移的可能性较小。两组的组织学、分级、激素和HER-2受体状态相当。除激素治疗外，老年人接受手术、放疗或化疗的可能性较小。
与NEBC患者相比，埃及的EBC患者表现为晚期疾病，接受手术、放疗或化疗的可能性较小。
