School of Pharmacy, Faculty of Medical and Health Sciences, The University of Auckland, New Zealand.
Int J Drug Policy. 2013 Sep;24(5):412-22. doi: 10.1016/j.drugpo.2013.02.002. Epub 2013 Mar 15.
The last decade has seen the emergence of a new phenomenon in recreational substance use with the availability of herbal and synthetic, unregulated, psychoactive drugs in the market place; alongside this, international concern has developed in relation to their use and associated harms. New Zealand (NZ) was one of the first countries to experience this new phenomenon, with products containing chemicals of the piperazine group - mainly benzylpiperazine (BZP) and trifluoromethylphenylpiperazine (TFMPP). In 2008, the NZ Government prohibited these substances, but allowed a 6-month amnesty period for possession. Our study aimed to obtain a measure of change in BZP use over time.
This study used a longitudinal, web-based survey, with data collected at two time points from the same participants. The first survey was carried out 3 months after BZP prohibition, and included retrospective questions for the 6 months preceding the survey. The second survey was conducted 9 months after prohibition and also included retrospective questions for the 6 months preceding the survey.
273 sets of paired data were identified. The use of BZP party pills (p<0.0001) and legally available smokeable products (p=0.002) reduced over time. A majority of users of party pills obtained them from friends or from their own stockpiled supplies. The misuse of prescription drugs (p=0.02) increased over time, whereas statistically significant increases in stimulant or alcohol use were not noted.
Following prohibition of piperazine-based party pills, we noted a significant reduction in the proportions of participants using them. The observed increase in the misuse of prescription medicines may relate to their perceived 'quality', or as being less 'illegal' than illicit drugs.
在过去的十年中,市场上出现了新的娱乐性药物,包括草药和合成的、不受监管的、具有精神活性的药物,与此同时,国际社会对这些药物的使用及其相关危害也表示关注。新西兰(NZ)是最早经历这种新现象的国家之一,其产品中含有哌嗪类化学物质-主要是苯甲哌嗪(BZP)和三氟甲基苯哌嗪(TFMPP)。2008 年,新西兰政府禁止这些物质,但允许拥有这些物质的人在 6 个月内赦免。我们的研究旨在衡量 BZP 使用随时间的变化。
本研究采用纵向、基于网络的调查,在同一参与者的两个时间点收集数据。第一次调查是在 BZP 禁令实施后 3 个月进行的,包括调查前 6 个月的回顾性问题。第二次调查是在禁令实施 9 个月后进行的,也包括调查前 6 个月的回顾性问题。
共确定了 273 组配对数据。BZP 派对药丸(p<0.0001)和合法可吸食产品(p=0.002)的使用随时间减少。大多数派对药丸的使用者是从朋友或自己储备的供应中获得的。处方药物的滥用(p=0.02)随时间增加,而兴奋剂或酒精的使用没有明显增加。
在禁止使用哌嗪类派对药丸后,我们注意到使用它们的参与者比例显著下降。观察到的处方药物滥用增加可能与它们被认为的“质量”有关,或者因为它们比非法药物更“合法”。