Fengler S A, Berenberg J L, Lee Y T
General Surgery Service, Tripler Army Medical Center, Honolulu, Hawaii 96859-5000.
Am Surg. 1990 Jun;56(6):335-8.
Among patients with various malignancies, three to 15 per cent may have associated idiopathic thrombosis. In a two-year period, we saw three patients with signs and symptoms demonstrating the association of neoplasia and coagulopathy. Their clinical courses and eventual outcomes are summarized. All had thrombophlebitis of multiple sites. There were difficulties in demonstrating their underlying occult malignancies, and all three patients showed resistance to oral anticoagulation drugs. Current hypotheses concerning the pathophysiology of coagulopathy associated with cancer are discussed, and recommendations for management of such patients were presented.
在患有各种恶性肿瘤的患者中，3%至15%可能伴有特发性血栓形成。在两年时间里，我们见到了三名有体征和症状表明肿瘤与凝血病有关联的患者。总结了他们的临床病程及最终结局。所有患者均有多处血栓性静脉炎。在查明其潜在的隐匿性恶性肿瘤方面存在困难，且所有三名患者对口服抗凝药物均有抵抗。讨论了目前关于癌症相关凝血病病理生理学的假说，并提出了对此类患者的管理建议。
