Adamson D J, Currie J M
Aberdeen Royal Infirmary.
Br J Clin Pract. 1993 Jul-Aug;47(4):190-1.
The increased incidence of intravascular thrombosis and thromboembolic episodes in patients with malignant disease is well documented. There have, however, been only two reports of covert malignancy in patients who continue to extend their deep vein thrombosis despite apparently adequate anticoagulation. Three patients are described in whom venous thrombosis steadily worsened despite a prothrombin time of at least twice normal. None had either obvious predisposing factors to thromboembolism or a family history of thrombotic disease. Recognition of this phenomenon can be helpful in avoiding delay in diagnosing malignancy in young patients.
恶性疾病患者血管内血栓形成和血栓栓塞事件的发生率增加已得到充分记录。然而，仅有两份报告称，尽管进行了看似充分的抗凝治疗，但仍有深静脉血栓形成持续扩展的患者存在隐匿性恶性肿瘤。本文描述了三名患者，尽管凝血酶原时间至少是正常的两倍，但静脉血栓仍持续恶化。他们均无明显的血栓栓塞诱发因素，也无血栓形成疾病家族史。认识到这一现象有助于避免年轻患者恶性肿瘤诊断的延误。
