Pitman R K, van der Kolk B A, Orr S P, Greenberg M S
Manchester Veterans Affairs Medical Center, NH.
Arch Gen Psychiatry. 1990 Jun;47(6):541-4. doi: 10.1001/archpsyc.1990.01810180041007.
We tested the hypothesis that exposure to a stimulus resembling the original traumatic event would induce naloxone-reversible analgesia in patients with posttraumatic stress disorder (PTSD). Eight medication-free Vietnam veterans with PTSD and eight veterans without PTSD, matched for age and combat severity, viewed a 15-minute videotape of dramatized combat under naloxone hydrochloride and placebo conditions in a randomized double-blind crossover design. In the placebo condition, the subjects with PTSD showed a 30% decrease in reported pain intensity ratings of standardized heat stimuli after the combat videotape. No decrease in pain ratings occurred in the subjects with PTSD in the naloxone condition. The subjects without PTSD did not show a decrease in pain ratings in either condition. The results are consistent with the induction of opioid-mediated stress-induced analgesia in the patients with PTSD.
让创伤后应激障碍（PTSD）患者接触类似原始创伤事件的刺激会诱发纳洛酮可逆性镇痛。我们采用随机双盲交叉设计，让8名未服用药物的患有PTSD的越南退伍军人和8名年龄及战斗经历严重程度相匹配的无PTSD退伍军人，在盐酸纳洛酮和安慰剂条件下观看一段15分钟的模拟战斗录像带。在安慰剂条件下，患有PTSD的受试者在观看战斗录像带后，报告的标准化热刺激疼痛强度评分下降了30%。在纳洛酮条件下，患有PTSD的受试者疼痛评分没有下降。无PTSD的受试者在两种条件下疼痛评分均未下降。这些结果与PTSD患者中阿片类物质介导的应激诱导镇痛的诱导情况一致。
