Department of Obstetrics and Gynecology, Clinica Universidad de Navarra, University of Navarra, Pamplona, Spain.
Int J Gynecol Cancer. 2013 May;23(4):680-4. doi: 10.1097/IGC.0b013e31828bdbb6.
The objective of this study was to assess whether there are differences on ultrasound features between epithelial ovarian cancer (EOC) type I and type II.
This was a retrospective study comprising 244 women (mean age, 55.2 years old) with histologically proven EOC treated at our institution over a 12-year period. Clinical (patient age and symptoms and tumor stage), ultrasound (tumor volume, tumor appearance on gray-scale ultrasound, and color score), and histopathologic records were reviewed. Tumors were classified as EOC type I or type II. Type I tumors comprise low-grade serous, low-grade endometrioid, clear cell, mucinous, and transitional cell carcinomas, whereas type II tumors comprise high-grade serous, high-grade endometrioid, malignant mixed mesodermal tumors, and undifferentiated carcinomas. Categorical variables were compared using χ(2) test. Continuous variables were compared using 1-way analysis of variance with Bonferroni post hoc test or Mann-Whitney U or Kruskal-Wallis test, depending on data distribution.
Sixty-seven women (27.5%) had type I EOC, and 177 (72.3%) had type II EOC. We observed that women with type I EOC were younger, presented asymptomatic at diagnosis more frequently, and had lower CA-125 levels and lower tumor stage than women with type II EOC. Type II EOCs were more frequently identified as a solid mass and were smaller lesions than type I EOC.
Some differences exist between type I and type II EOC in clinical and ultrasound manifestations. Although the clinical significance of these findings is still to be determined, this information could provide some clues to clinicians faced with the diagnosis of ovarian cancer.
本研究旨在评估上皮性卵巢癌（EOC）Ⅰ型和Ⅱ型在超声特征上是否存在差异。
这是一项回顾性研究，纳入了在我院接受治疗的 244 名组织学证实为 EOC 的女性患者（平均年龄 55.2 岁），研究时间为 12 年。回顾了临床（患者年龄、症状和肿瘤分期）、超声（肿瘤体积、灰阶超声上的肿瘤外观和彩色评分）和组织病理学记录。肿瘤分为 EOC Ⅰ型或Ⅱ型。Ⅰ型肿瘤包括低级别浆液性、低级别子宫内膜样、透明细胞、黏液性和移行细胞癌，而Ⅱ型肿瘤包括高级别浆液性、高级别子宫内膜样、恶性混合性中胚叶肿瘤和未分化癌。采用卡方检验比较分类变量，采用单因素方差分析（Bonferroni 事后检验）或 Mann-Whitney U 检验或 Kruskal-Wallis 检验比较连续变量，具体取决于数据分布。
67 名女性（27.5%）为Ⅰ型 EOC，177 名女性（72.3%）为Ⅱ型 EOC。我们观察到，Ⅰ型 EOC 患者更年轻，诊断时无症状更为常见，CA-125 水平更低，肿瘤分期更低。Ⅱ型 EOC 更常被识别为实性肿块，且肿瘤体积小于Ⅰ型 EOC。
Ⅰ型和Ⅱ型 EOC 在临床和超声表现上存在一些差异。尽管这些发现的临床意义仍有待确定，但这些信息可能为面临卵巢癌诊断的临床医生提供一些线索。
