Holme R J, Fouraker B D, Schanzlin D J
Department of Ophthalmology, Bethesda Eye Institute, St. Louis, MO 63110.
Arch Ophthalmol. 1990 Jun;108(6):876-81. doi: 10.1001/archopht.1990.01070080120048.
We used an argon fluoride excimer laser (193 nm) to perform anterior corneal surface ablation in New Zealand white rabbits (25 eyes) using both en face and tangential methods. We followed up the animals for 90 days using slit-lamp photography and pachymetry at predetermined intervals. We also examined selected tissues with scanning electron microscopy and transmission electron microscopy. Immediate and subsequent examinations revealed significant differences in clarity between the two groups. When viewed through slit-lamp microscopy, the rabbits undergoing the en face method exhibited hazy corneas and irregular surfaces, whereas the corneas that underwent tangential keratectomy demonstrated less haze and fewer surface irregularities. Through histologic study and electron microscopy, we corroborated this finding. At 30 days, there was a statistically significant difference in clarity between en face--treated corneas and those treated tangentially.
我们使用氟化氩准分子激光（193纳米），采用直视和切线两种方法，对新西兰白兔的25只眼睛进行角膜前表面消融。我们在预定的时间间隔，利用裂隙灯摄影和角膜厚度测量仪对动物进行了90天的随访。我们还通过扫描电子显微镜和透射电子显微镜检查了选定的组织。即时和后续检查显示两组在清晰度上有显著差异。通过裂隙灯显微镜观察，采用直视方法的兔子角膜呈现模糊且表面不规则，而接受切线角膜切除术的角膜则显示出较少的 haze 和较少的表面不规则。通过组织学研究和电子显微镜检查，我们证实了这一发现。在30天时，直视治疗的角膜与切线治疗的角膜在清晰度上存在统计学上的显著差异。 （注：原文中“haze”未准确翻译，可能是医学专业术语“雾状混浊”之类，这里保留英文，建议结合医学知识进一步准确翻译）
