Hu Si-Long, Yang Zhong-Yi, Zhou Zheng-Rong, Yu Xian-Jun, Ping Bo, Zhang Ying-Jian
Department of Nuclear Medicine, Fudan University Shanghai Cancer Center, Shanghai, China.
Nucl Med Commun. 2013 Jun;34(6):533-9. doi: 10.1097/MNM.0b013e328360668a.
Maximum standardized uptake value (SUV(max)) is a marker of tumor glucose metabolism detected by [(18)F]-fluorodeoxyglucose ((18)F-FDG) PET/computed tomography (PET/CT) and reflects tumor aggressiveness. The aim of the study was to evaluate the value of SUV(max) in differentiating benign from malignant solitary pancreatic lesions and explore the correlation between SUV(max) and tumor proliferative activity.
F-FDG PET/CT scans were performed in 80 patients with solitary pancreatic lesions who were scheduled for resective surgery. The relationships between SUV(max) and postoperative pathologic diagnosis, histologic grade, and Ki-67 proliferation index (PI) were analyzed.
Of these 80 patients, 54 had malignant lesions. The SUV(max) of malignant tumors (6.3 ± 2.4) was significantly greater than that of benign lesions (2.9 ± 2.0) (P<0.001). Receiver-operating characteristic curve analysis showed that the SUV(max) cutoff value of 3.5 had a high sensitivity (92.6%) and specificity (76.9%) for the diagnosis of malignancies. Among pancreatic cancers with low (Ki-67<5%), moderate (5% ≤ Ki-67<50%), and high (Ki-67 ≥ 50%) PI, SUV(max) increased significantly from 4.2 ± 1.2, through 6.0 ± 1.7, to 8.6 ± 2.5 (P<0.001). The SUV(max) had a positive correlation with Ki-67 PI (P<0.001, r=0.60).
The SUV(max) of F-FDG PET/CT can be used in the differential diagnosis of solitary pancreatic lesions and can also aid in the prediction of proliferative activity of pancreatic cancer.
最大标准化摄取值（SUV(max)）是通过[（18）F] - 氟脱氧葡萄糖（（18）F - FDG）PET/计算机断层扫描（PET/CT）检测到的肿瘤葡萄糖代谢标志物，反映肿瘤侵袭性。本研究的目的是评估SUV(max)在鉴别孤立性胰腺病变的良恶性方面的价值，并探讨SUV(max)与肿瘤增殖活性之间的相关性。
对80例计划进行切除手术的孤立性胰腺病变患者进行了F - FDG PET/CT扫描。分析了SUV(max)与术后病理诊断、组织学分级和Ki - 67增殖指数（PI）之间的关系。
这80例患者中，54例为恶性病变。恶性肿瘤的SUV(max)（6.3±2.4）显著高于良性病变（2.9±2.0）（P<0.001）。受试者操作特征曲线分析表明，SUV(max)截断值为3.5时，对恶性肿瘤诊断具有较高的敏感性（92.6%）和特异性（76.9%）。在低（Ki - 67<5%）、中（5%≤Ki - 67<50%）、高（Ki - 67≥50%）PI的胰腺癌中，SUV(max)从4.2±1.2、经6.0±1.7显著增加至8.6±2.5（P<0.001）。SUV(max)与Ki - 67 PI呈正相关（P<0.001，r = 0.60）。
F - FDG PET/CT的SUV(max)可用于孤立性胰腺病变的鉴别诊断，也有助于预测胰腺癌的增殖活性。
