Keenan Research Centre of the Li Ka Shing Knowledge Institute, St. Michael’s Hospital, Toronto, Ontario, Canada.
Circ J. 2013;77(4):849-56. doi: 10.1253/circj.cj-13-0236. Epub 2013 Mar 16.
Although seemingly diverse, the tissue injury at sites of diabetic complications, whether in the heart, kidneys or eyes, shares the common histopathological feature of endothelial cell loss, a consequence of both increased cell death and deficient regeneration. In medium-sized and larger arteries the loss of the protective lining contributes to the atherosclerotic process, while at sites of microvascular disease endothelial cell loss leads to capillary rarefaction and ischemia. The pathophysiology of these changes and their consequences on organ structure and function in diabetes are reviewed, and the potential for endothelial regenerative strategies to enhance repair and ameliorate the long-term complications of diabetes is explored.
尽管糖尿病并发症的发生部位看似多种多样，但无论是心脏、肾脏还是眼睛，组织损伤都具有共同的组织病理学特征，即内皮细胞丧失，这是细胞死亡增加和再生不足的结果。在中等大小和更大的动脉中，保护层的丧失导致动脉粥样硬化过程，而在微血管疾病部位，内皮细胞丧失导致毛细血管稀疏和缺血。本文综述了这些变化的病理生理学及其对糖尿病器官结构和功能的影响，并探讨了内皮再生策略增强修复和改善糖尿病长期并发症的潜力。
