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Mitochondrial Dysfunction and Myocardial Ischemia-Reperfusion: Implications for Novel Therapies.线粒体功能障碍与心肌缺血再灌注：对新型疗法的启示
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姜酮酸通过调控自噬在 T2DM 缺血/再灌注损伤中的保护作用。

The protective role of carnosic acid in ischemic/reperfusion injury through regulation of autophagy under T2DM.

机构信息

1 Department of Cardiovascular Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

2 Department of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

出版信息

Exp Biol Med (Maywood). 2019 May;244(7):602-611. doi: 10.1177/1535370219840987. Epub 2019 Apr 4.

DOI:10.1177/1535370219840987
PMID:30947537
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6545691/
Abstract

We have provided, for the first time, evidence that carnosic acid (CA) attenuates ischemia-reperfusion injury of diabetic myocardium, i.e. diabetic myocardial ischemia/reperfusion (DMI/R) injury, via enhancement of autophagy. A greater understanding of the target molecule in CA-enhanced autophagy is necessary for the development of potential chemotherapy for DMI/R injury.

摘要

我们首次提供了证据，表明 carnosic 酸（CA）通过增强自噬来减轻糖尿病心肌的缺血再灌注损伤，即糖尿病心肌缺血/再灌注（DMI/R）损伤。为了开发针对 DMI/R 损伤的潜在化学疗法，有必要更深入地了解 CA 增强自噬中的靶分子。