RNA 聚合酶 II 通过抑制染色质进行调控。
Chaperoning RNA Polymerase II through repressive chromatin.
机构信息
Sprott Center for Stem Cell Research, Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
出版信息
EMBO J. 2013 Apr 17;32(8):1067-8. doi: 10.1038/emboj.2013.64. Epub 2013 Mar 15.
Abstract
EMBO J (2013) 32: 1075–1086 doi:; DOI: 10.1038/emboj.2013.54; published online March 15 2013 The histone chaperone Spt6 is known to facilitate transcriptional elongation while preventing spurious initiation of transcription within the coding region of genes. A recent publication in (Wang et al, 2013) identifies an additional mechanism by which Spt6 promotes gene expression by demonstrating that it tethers the histone demethylase UTX/KDM6A to the elongating RNA Polymerase II, thereby enabling the removal of repressive H3K27me3 marks within developmentally important muscle genes.
摘要
EMBO J (2013) 32: 1075–1086 doi:; DOI: 10.1038/emboj.2013.54; published online March 15 2013 组蛋白伴侣 Spt6 已知可促进转录延伸，同时防止基因编码区内转录的错误起始。最近在 （Wang 等人，2013）的一项出版物中确定了 Spt6 通过促进基因表达的另一种机制，证明它将组蛋白去甲基酶 UTX/KDM6A 连接到延伸的 RNA 聚合酶 II，从而使发育重要的肌肉基因内的抑制性 H3K27me3 标记得以去除。
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