一氧化氮形成亚硝基硫醇的细胞机制概述
A Conspectus of Cellular Mechanisms of Nitrosothiol Formation from Nitric Oxide.
作者信息
Li Qian, Lancaster Jack R
机构信息
Center for Free Radical Biology Departments of Anesthesiology, University of Alabama Birmingham, Birmingham, AL 35294.
出版信息
For Immunopathol Dis Therap. 2012;3(2):183-191. doi: 10.1615/ForumImmunDisTher.2012006372.
Abstract
Although chemical mechanisms for the formation of nitrosothiol from •NO have been studied extensively "in the test tube", surprisingly little is known regarding the mechanism(s) of how nitrosothiols are formed . This lack of understanding has hampered more general acceptance of the concept of cysteine nitrosothiol formation as a generally applicable, regulated, and functionally significant protein posttranslational modification (as opposed to multiple other •NO-induced thiol modifications). Here we provide a brief overview/summary of the cellular formation of nitrosothiols from •NO two possible mechanisms involving oxygen or transition metals.
摘要
尽管在“试管”中已经广泛研究了由•NO形成亚硝基硫醇的化学机制，但令人惊讶的是，对于亚硝基硫醇的形成机制知之甚少。这种认识上的不足阻碍了半胱氨酸亚硝基硫醇形成这一概念被更广泛地接受，即它是一种普遍适用、受调控且具有功能意义的蛋白质翻译后修饰（与多种其他•NO诱导的硫醇修饰相对）。在这里，我们简要概述了由•NO形成亚硝基硫醇的细胞机制——涉及氧或过渡金属的两种可能机制。
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