Division of Urology, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.
Urolithiasis. 2013 Apr;41(2):105-9. doi: 10.1007/s00240-012-0524-9. Epub 2013 Feb 6.
The purpose of this study is to derive approximate estimates of ion-activity products of CaOx (APCaOx) and CaP (APCaP) useful for spot urine or other less well defined short-term urine collections. In accordance with previously applied and described principles for estimating ion-activity products, the intention was to derive simplified estimates of AP(CaOx)CONC and AP(CaP)CONC by using urine concentrations of the most important determinants of APCaOx and APCaP. A comparison thus was made between estimates derived in that manner and AP(CaOx) index and AP(CaP) index obtained from calculations based on analysis of 24 h urine samples. The best fit between estimates of AP(CaOx) index in 24 h urine and AP(CaOx) indexCONC was obtained with the following formula (r = 0.99; p = 0.0000): [Formula in text] The corresponding formula for AP (CaP) indexCONC was derived from comparison with the corresponding calculations of AP(CaP) index in 24 h urine (r = 0.91; p = 0.0000): [Formula in text] The proposed simplified formulas enable calculation of approximate estimates of APCaOx and APCaP in spot-urine samples or any kind of urine collection for which duration of the collection period is less well known and by using the concentrations (c) of the variables in mmol/L in the two formulas.
本研究旨在推导用于即时尿或其他定义不明确的短期尿液收集的 CaOx（APCaOx）和 CaP（APCaP）离子活度积的近似估计值。根据先前应用和描述的估计离子活度积的原则，我们意图通过使用最能确定 APCaOx 和 APCaP 的决定因素的尿浓度来推导 AP(CaOx)CONC 和 AP(CaP)CONC 的简化估计值。因此，将通过这种方式得出的估计值与 24 小时尿液样本分析得出的 AP(CaOx) 指数和 AP(CaP) 指数进行了比较。通过以下公式，在 24 小时尿液中获得了 AP(CaOx) 指数与 AP(CaOx) 指数 CONC 之间的最佳拟合（r = 0.99；p = 0.0000）：[公式在文本中] 用于推导 AP (CaP) 指数 CONC 的相应公式是通过与 24 小时尿液中相应的 AP(CaP) 指数计算进行比较得出的（r = 0.91；p = 0.0000）：[公式在文本中] 所提出的简化公式可用于计算即时尿样或任何已知收集期持续时间较短的尿液收集的 APCaOx 和 APCaP 的近似估计值，并且使用两个公式中以 mmol/L 为单位的变量（c）的浓度。
