Department of Surgery, Seoul National University Bundang Hospital, 300 Gumidong, Bundanggu, Seongnamsi, Gyeonggido, 463-707, Korea.
Fam Cancer. 2013 Dec;12(4):621-8. doi: 10.1007/s10689-013-9625-z.
The objective of this study was to identify factors that affect the decision to undergo risk-reducing salpingo-oophorectomy (RRSO) in BRCA1 or BRCA2 mutations carriers in South Korea. The medical records of 124 women who had been found to have BRCA1 or BRCA2 gene mutation at our institution between May 2003 and December 2011 were reviewed. The carriers were divided into RRSO and non-RRSO groups for comparison of their clinicopathologic, socio-economic, and psychosocial factors. Of the 71 carriers eligible for RRSO, 21 had undergone RRSO. In univariate analysis, classification of carriers into 3 groups by decade of life (4th, 5th, or 6th and later decade) and subsequent analysis revealed that 52.6% of carriers in the 5th decade had undergone RRSO, a rate significantly higher than that of the other age groups (p = 0.007). The RRSO rate was higher in carriers with a personal history of breast cancer than in those without (39.2% vs. 5.0%, p = 0.004), in carriers with a family history of breast cancer than in those without (35.5% vs. 11.8%, p = 0.065), and in carriers with a family history of ovarian cancer than in those carriers without a family history (66.7% vs. 24.2%, p = 0.016). Multivariate analysis identified age and personal history of breast cancer as independent factors affecting the decision to undergo RRSO. Age and personal history of breast cancer are important factors in the decision to undergo, and should thus be considered when counseling BRCA1/2 mutation carriers.
本研究旨在确定影响韩国 BRCA1 或 BRCA2 基因突变携带者进行风险降低输卵管卵巢切除术（RRSO）决策的因素。回顾了 2003 年 5 月至 2011 年 12 月期间在我院发现 BRCA1 或 BRCA2 基因突变的 124 名女性的病历。将携带者分为 RRSO 和非 RRSO 组，比较其临床病理、社会经济和心理社会因素。在符合 RRSO 条件的 71 名携带者中，有 21 名接受了 RRSO。在单因素分析中，将携带者按生活的十年（第 4、5 或第 6 个及以后的十年）分为 3 组进行分类，随后的分析显示，第 5 个十年的携带者中有 52.6%接受了 RRSO，这一比率明显高于其他年龄组（p=0.007）。有乳腺癌个人病史的携带者 RRSO 率高于无乳腺癌个人病史的携带者（39.2% vs. 5.0%，p=0.004），有乳腺癌家族史的携带者 RRSO 率高于无乳腺癌家族史的携带者（35.5% vs. 11.8%，p=0.065），有卵巢癌家族史的携带者 RRSO 率高于无卵巢癌家族史的携带者（66.7% vs. 24.2%，p=0.016）。多因素分析确定年龄和乳腺癌个人史是影响 RRSO 决策的独立因素。年龄和乳腺癌个人史是进行 RRSO 的重要因素，因此在咨询 BRCA1/2 基因突变携带者时应予以考虑。
