Martinez Soledad, Miranda Elvira, Kim Patrick, Pollanen Michael S
Servicio Medico Legal, Av. La Paz 1012, Independencia, Santiago, Chile.
Forensic Sci Med Pathol. 2013 Sep;9(3):403-6. doi: 10.1007/s12024-013-9418-6. Epub 2013 Mar 17.
We report a case of sudden unexpected death in an adult woman from florid myocarditis with necrosis, replacement fibrosis, and diffuse infiltration of the myocardium by eosinophils and conspicuous giant cells. Clinical history revealed that 3 weeks prior to death, shortly after commencing antibiotic therapy for the treatment of traumatic wound of a finger, she presented to the emergency room with a hypersensitivity reaction characterized by facial rash with edema and generalized pruritus. She was treated with antihistamines and discharged. The clinico-pathological correlation suggests a link between drug hypersensitivity and the giant cell myocarditis.
我们报告一例成年女性因暴发性心肌炎伴坏死、替代性纤维化以及嗜酸性粒细胞和显著巨细胞弥漫性浸润导致的意外猝死。临床病史显示，在死亡前3周，她因手指创伤伤口开始抗生素治疗后不久，因面部皮疹伴水肿和全身瘙痒的过敏反应就诊于急诊室。她接受了抗组胺药治疗后出院。临床病理相关性提示药物过敏与巨细胞心肌炎之间存在联系。
