Daniels P R, Berry G J, Tazelaar H D, Cooper L T
Department of Medicine, Mayo Clinic and Foundation, Rochester, MN 55905, USA.
Cardiovasc Pathol. 2000 Sep-Oct;9(5):287-91. doi: 10.1016/s1054-8807(00)00049-1.
Adverse drug effects on the myocardium are often classified into toxic and hypersensitivity forms of myocarditis, each with distinct histologic findings. In contrast, giant cell myocarditis (GCM) is generally not associated with adverse drug reactions and has unique histopathologic features. We report four cases of adverse drug reactions in which the histologic findings were characteristic of GCM. The clinical recognition that GCM may be a manifestation of an adverse drug reaction is important, since the prognosis and treatment of this entity may be different from that of other forms of myocarditis.
药物对心肌的不良影响通常分为中毒性和过敏性心肌炎两种形式，每种形式都有独特的组织学表现。相比之下，巨细胞心肌炎（GCM）一般与药物不良反应无关，具有独特的组织病理学特征。我们报告了4例药物不良反应病例，其组织学表现具有GCM的特征。认识到GCM可能是药物不良反应的一种表现具有重要意义，因为该疾病的预后和治疗可能与其他形式的心肌炎不同。
