耐受缺血——一门日益复杂的生物学。
Tolerance to ischemia - an increasingly complex biology.
机构信息
Neuroscience Institute, Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, GA, 30310-1495 ; Department of Neurobiology, Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, GA, 30310-1495 ; Department of Pharmacology, Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, GA, 30310-1495.
出版信息
Transl Stroke Res. 2013 Feb;4(1):40-50. doi: 10.1007/s12975-012-0246-x. Epub 2013 Jan 11.
Abstract
In this review we identify and discuss some of the genomics studies of preconditioning and the ischemic tolerance phenomenon. Such studies have been attempted in multiple species, using different array technologies and with different preconditioning and tolerance models. In addition, studies are starting to reveal epigenetic mechanisms and modifiers of tolerance and preconditioning. Together these studies are starting to reveal some of the immense complexity of the ischemic tolerance phenomenon, yet further studies await to be performed.
摘要
在这篇综述中，我们确定并讨论了一些关于预处理和缺血耐受现象的基因组学研究。这些研究已经在多个物种中进行，使用了不同的阵列技术和不同的预处理和耐受模型。此外，研究开始揭示耐受和预处理的表观遗传机制和修饰因子。这些研究一起开始揭示缺血耐受现象的巨大复杂性，但还需要进行更多的研究。
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