• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Tolerance to ischemia - an increasingly complex biology.耐受缺血——一门日益复杂的生物学。
Transl Stroke Res. 2013 Feb;4(1):40-50. doi: 10.1007/s12975-012-0246-x. Epub 2013 Jan 11.
2
Genetic animal models of preconditioning.预处理的遗传动物模型。
Transl Stroke Res. 2013 Feb;4(1):51-5. doi: 10.1007/s12975-012-0218-1. Epub 2012 Nov 22.
3
Genetics and genomics of ischemic tolerance: focus on cardiac and cerebral ischemic preconditioning.缺血耐受的遗传学和基因组学：关注心脏和脑缺血预处理。
Pharmacogenomics. 2012 Nov;13(15):1741-57. doi: 10.2217/pgs.12.157.
4
Epigenetics and the environment: in search of the "toleroasome" vital to execution of ischemic preconditioning.表观遗传学与环境：探寻执行缺血预处理的关键“耐受体”。
Transl Stroke Res. 2013 Feb;4(1):56-62. doi: 10.1007/s12975-012-0235-0. Epub 2013 Jan 8.
5
Putative endogenous mediators of preconditioning-induced ischemic tolerance in rat brain identified by genomic and proteomic analysis.通过基因组和蛋白质组学分析鉴定的大鼠脑中预处理诱导的缺血耐受的假定内源性介质。
J Neurochem. 2004 Apr;89(1):73-89. doi: 10.1111/j.1471-4159.2004.02316.x.
6
[Ischemic tolerance (preconditioning) of the brain].[大脑的缺血耐受性（预处理）]
Anesteziol Reanimatol. 2008 Mar-Apr(2):41-7.
7
Induction of cerebral ischemic tolerance by erythromycin preconditioning reprograms the transcriptional response to ischemia and suppresses inflammation.红霉素预处理诱导脑缺血耐受可重新编程对缺血的转录反应并抑制炎症。
Anesthesiology. 2007 Mar;106(3):538-47. doi: 10.1097/00000542-200703000-00019.
8
From rapid to delayed and remote postconditioning: the evolving concept of ischemic postconditioning in brain ischemia.从速发型到迟发型和远程后处理：脑缺血中缺血后处理概念的不断发展。
Curr Drug Targets. 2012 Feb;13(2):173-87. doi: 10.2174/138945012799201621.
9
The neuroprotective mechanism of brain ischemic preconditioning.脑缺血预处理的神经保护机制。
Acta Pharmacol Sin. 2009 Aug;30(8):1071-80. doi: 10.1038/aps.2009.105. Epub 2009 Jul 20.
10
Preconditioning with recombinant high-mobility group box 1 induces ischemic tolerance in a rat model of focal cerebral ischemia-reperfusion.用重组高迁移率族蛋白B1进行预处理可在局灶性脑缺血再灌注大鼠模型中诱导缺血耐受。
J Neurochem. 2016 May;137(4):576-88. doi: 10.1111/jnc.13611. Epub 2016 Apr 1.

引用本文的文献

1
Endogenous neuroprotective mechanism of ATP2B1 in transcriptional regulation of ischemic preconditioning.ATP2B1在缺血预处理转录调控中的内源性神经保护机制。
Am J Transl Res. 2021 Mar 15;13(3):1170-1183. eCollection 2021.
2
Further application of hyperbaric oxygen in prostate cancer.高压氧在前列腺癌中的进一步应用。
Med Gas Res. 2019 Jan 9;8(4):167-171. doi: 10.4103/2045-9912.248268. eCollection 2018 Oct-Dec.
3
Regulation of gene expression in ischemic preconditioning in the brain.脑缺血预处理中基因表达的调控
Cond Med. 2017 Dec;1(1):47-56. Epub 2017 Dec 15.
4
Magnesium induces preconditioning of the neonatal brain via profound mitochondrial protection.镁通过深度的线粒体保护诱导新生儿脑的预处理。
J Cereb Blood Flow Metab. 2019 Jun;39(6):1038-1055. doi: 10.1177/0271678X17746132. Epub 2017 Dec 5.
5
Remote Limb Ischemic Preconditioning: A Neuroprotective Technique in Rodents.远程肢体缺血预处理：一种在啮齿动物中的神经保护技术。
J Vis Exp. 2015 Jun 2(100):e52213. doi: 10.3791/52213.
6
Dynamic changes in DNA methylation in ischemic tolerance.缺血耐受中DNA甲基化的动态变化。
Front Neurol. 2015 May 15;6:102. doi: 10.3389/fneur.2015.00102. eCollection 2015.
7
The mitochondrial uncoupler DNP triggers brain cell mTOR signaling network reprogramming and CREB pathway up-regulation.线粒体解偶联剂2,4-二硝基苯酚触发脑细胞雷帕霉素靶蛋白（mTOR）信号网络重编程及环磷腺苷效应元件结合蛋白（CREB）通路上调。
J Neurochem. 2015 Aug;134(4):677-92. doi: 10.1111/jnc.13176. Epub 2015 Jun 19.
8
A critical review of mechanisms regulating remote preconditioning-induced brain protection.对调节远程预处理诱导脑保护机制的批判性综述。
J Appl Physiol (1985). 2015 Nov 15;119(10):1135-42. doi: 10.1152/japplphysiol.00169.2015. Epub 2015 May 7.
9
Oxygen and glucose deprivation induces widespread alterations in mRNA translation within 20 minutes.氧糖剥夺在20分钟内会引起mRNA翻译的广泛改变。
Genome Biol. 2015 May 6;16(1):90. doi: 10.1186/s13059-015-0651-z.
10
Ischemic conditioning-induced endogenous brain protection: Applications pre-, per- or post-stroke.缺血预处理诱导的内源性脑保护：在卒中前、卒中时或卒中后的应用。
Exp Neurol. 2015 Oct;272:26-40. doi: 10.1016/j.expneurol.2015.04.009. Epub 2015 Apr 18.

本文引用的文献

1
The end of "small science"?“小科学”的终结？
Science. 2012 Sep 28;337(6102):1583. doi: 10.1126/science.1230529.
2
Gene expression analysis to identify molecular correlates of pre- and post-conditioning derived neuroprotection.基因表达分析鉴定预处理和后处理诱导的神经保护的分子相关性。
J Mol Neurosci. 2012 Jun;47(2):322-39. doi: 10.1007/s12031-012-9751-3. Epub 2012 Apr 1.
3
Differential DNA methylation patterns define status epilepticus and epileptic tolerance.差异性 DNA 甲基化模式定义了癫痫持续状态和癫痫耐受状态。
J Neurosci. 2012 Feb 1;32(5):1577-88. doi: 10.1523/JNEUROSCI.5180-11.2012.
4
Remote ischemic limb preconditioning after subarachnoid hemorrhage: a phase Ib study of safety and feasibility.蛛网膜下腔出血后肢体远程缺血预处理：安全性和可行性的 Ib 期研究。
Stroke. 2011 May;42(5):1387-91. doi: 10.1161/STROKEAHA.110.605840. Epub 2011 Mar 17.
5
Functional identification of neuroprotective molecules.神经保护分子的功能鉴定。
PLoS One. 2010 Nov 24;5(11):e15008. doi: 10.1371/journal.pone.0015008.
6
Neuroprotection induced in vitro by ischemic preconditioning and postconditioning: modulation of apoptosis and PI3K-Akt pathways.缺血预处理和后处理诱导的体外神经保护：细胞凋亡和 PI3K-Akt 通路的调节。
J Mol Neurosci. 2011 Mar;43(3):428-42. doi: 10.1007/s12031-010-9461-7. Epub 2010 Oct 15.
7
Epileptic tolerance is associated with enduring neuroprotection and uncoupling of the relationship between CA3 damage, neuropeptide Y rearrangement and spontaneous seizures following intra-amygdala kainic acid-induced status epilepticus in mice.癫痫耐受与神经保护有关，并使内侧杏仁核红藻氨酸诱导的癫痫持续状态后 CA3 损伤、神经肽 Y 重排和自发性癫痫之间的关系解耦。
Neuroscience. 2010 Dec 1;171(2):556-65. doi: 10.1016/j.neuroscience.2010.09.003. Epub 2010 Sep 17.
8
MicroRNAs induced during ischemic preconditioning.缺血预处理诱导的 microRNAs。
Stroke. 2010 Aug;41(8):1646-51. doi: 10.1161/STROKEAHA.110.579649. Epub 2010 Jun 24.
9
Possible involvement of DNA methylation in NKCC1 gene expression during postnatal development and in response to ischemia.可能涉及 DNA 甲基化在 NKCC1 基因表达在出生后发育过程中和对缺血的反应。
J Neurochem. 2010 Jul;114(2):520-9. doi: 10.1111/j.1471-4159.2010.06772.x. Epub 2010 Apr 28.
10
Polycomb group proteins as epigenetic mediators of neuroprotection in ischemic tolerance.多梳蛋白作为缺血耐受中神经保护的表观遗传介质。
Sci Signal. 2010 Mar 2;3(111):ra15. doi: 10.1126/scisignal.2000502.

耐受缺血——一门日益复杂的生物学。

Tolerance to ischemia - an increasingly complex biology.

机构信息

Neuroscience Institute, Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, GA, 30310-1495 ; Department of Neurobiology, Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, GA, 30310-1495 ; Department of Pharmacology, Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, GA, 30310-1495.

出版信息

Transl Stroke Res. 2013 Feb;4(1):40-50. doi: 10.1007/s12975-012-0246-x. Epub 2013 Jan 11.

DOI:10.1007/s12975-012-0246-x
PMID:23504451
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3596882/
Abstract

In this review we identify and discuss some of the genomics studies of preconditioning and the ischemic tolerance phenomenon. Such studies have been attempted in multiple species, using different array technologies and with different preconditioning and tolerance models. In addition, studies are starting to reveal epigenetic mechanisms and modifiers of tolerance and preconditioning. Together these studies are starting to reveal some of the immense complexity of the ischemic tolerance phenomenon, yet further studies await to be performed.

摘要

在这篇综述中，我们确定并讨论了一些关于预处理和缺血耐受现象的基因组学研究。这些研究已经在多个物种中进行，使用了不同的阵列技术和不同的预处理和耐受模型。此外，研究开始揭示耐受和预处理的表观遗传机制和修饰因子。这些研究一起开始揭示缺血耐受现象的巨大复杂性，但还需要进行更多的研究。