Streeten D H, Anderson G H, Wagner S
Department of Medicine, State University of New York Health Science Center, Syracuse.
Am J Hypertens. 1990 May;3(5 Pt 1):360-5. doi: 10.1093/ajh/3.5.360.
There is substantial evidence to show that correction of the causes of secondary forms of hypertension usually but certainly not always restores blood pressure to normal. We have analyzed the effect of age on the response of the blood pressure to the removal of the cause of hypertension in groups of patients with primary aldosteronism, renovascular hypertension, Cushing's syndrome and hypothyroid hypertension. In the patients studied, surgical or medical elimination of the mechanism responsible for the hypertension when the patients were below the age of 40 reduced diastolic blood pressure 1 to 2 years later to below 90 mm Hg in 24 of 25 patients. In the patients who were treated when they were over 40 years of age, blood pressure remained above 90 mm Hg after corrective treatment in 23 of 61 individuals (38%). In the 4 groups studied there was a significant correlation between age and post-treatment systolic and/or diastolic blood pressure. The findings indicate the importance of correcting secondary hypertension at an early age.
有大量证据表明，纠正继发性高血压的病因通常（但肯定不总是）能使血压恢复正常。我们分析了年龄对原发性醛固酮增多症、肾血管性高血压、库欣综合征和甲状腺功能减退性高血压患者组中血压对去除高血压病因反应的影响。在所研究的患者中，当患者年龄在40岁以下时，通过手术或药物消除导致高血压的机制，25名患者中有24名在1至2年后舒张压降至90毫米汞柱以下。在40岁以上接受治疗的患者中，61名个体中有23名（38%）在接受矫正治疗后血压仍高于90毫米汞柱。在所研究的4组中，年龄与治疗后收缩压和/或舒张压之间存在显著相关性。这些发现表明早期纠正继发性高血压的重要性。
