Centre for Chronic Disease, School of Medicine, University of Queensland, Queensland, Australia.
Epidemiol Infect. 2013 Dec;141(12):2497-502. doi: 10.1017/S0950268813000605. Epub 2013 Mar 18.
This study examined the relationship between body mass index (BMI) and the risk of pneumonia in Aboriginal Australians. A total of 677 adults aged 20-60 years were followed up from the baseline examination during 1992-1995 to June 2012. The pneumonia events were identified through hospital records. Pneumonia incident rates were calculated according to BMI groups. Hazard ratios were computed using Cox regression adjusting for age, smoking and alcohol consumption status. The incident rate of pneumonia was 13.3/1000 person-years, and this rate was significantly higher in females than males (hazard ratio = 1.5). Compared to males with normal BMI (18.5-24.9 kg/m²), the adjusted hazard ratio was 3.5 for males with lowest BMI (P < 0.01). Low BMI was significantly associated with a higher risk of hospitalized pneumonia for Aboriginal males. However, the U-shaped trend of this association indicates that the risk of pneumonia is likely to be associated with both low and high BMI.
本研究旨在探讨身体质量指数(BMI)与澳大利亚原住民肺炎风险之间的关系。1992 年至 1995 年期间,共有 677 名年龄在 20 至 60 岁的成年人参与了基线检查,随访至 2012 年 6 月。肺炎事件通过医院记录确定。根据 BMI 分组计算肺炎的发生率。使用 Cox 回归校正年龄、吸烟和饮酒状况后计算危险比。肺炎的发生率为 13.3/1000 人年,女性的发生率明显高于男性(危险比=1.5)。与正常 BMI(18.5-24.9 kg/m²)的男性相比,最低 BMI(P<0.01)的男性调整后的危险比为 3.5。低 BMI 与澳大利亚原住民男性住院肺炎的风险显著相关。然而,这种关联的 U 型趋势表明,肺炎的风险可能与低 BMI 和高 BMI 都有关。