Lampropoulou-Adamidou Kalliopi, Lelovas Pavlos, Karadimas Eleftherios V, Liakou Chrysoula, Triantafillopoulos Ioannis K, Dontas Ismene, Papaioannou Nikolaos A
3rd Orthopaedic Department, Faculty of Medicine, School of Health Sciences, KAT Hospital, University of Athens, 2 Nikis Street, Athens, 14561, Greece,
Eur J Orthop Surg Traumatol. 2014 Apr;24(3):263-71. doi: 10.1007/s00590-013-1205-2. Epub 2013 Mar 13.
Osteoarthritis (OA) is a major cause of suffering for millions of people. Investigating the disease directly on humans may be challenging. The aim of the present study is to investigate the advantages and limitations of the animal models currently used in OA research. The animal models are divided into induced and spontaneous. Induced models are further subdivided into surgical and chemical models, according to the procedure used to induce OA. Surgical induction of OA is the most commonly used procedure, which alters the exerted strain on the joint and/or alter load bearing leading to instability of the joint and induction of OA. Chemical models are generated by intra-articular injection of modifying factors or by systemically administering noxious agents, such as quinolones. Spontaneous models include naturally occurring and genetic models. Naturally occurring OA is described in certain species, while genetic models are developed by gene manipulation. Overall, there is no single animal model that is ideal for studying degenerative OA. However, in the present review, an attempt is made to clarify the most appropriate use of each model.
骨关节炎（OA）是数百万人遭受痛苦的主要原因。直接在人体上研究这种疾病可能具有挑战性。本研究的目的是调查目前用于OA研究的动物模型的优缺点。动物模型分为诱导型和自发型。根据诱导OA的程序，诱导型模型进一步细分为手术模型和化学模型。手术诱导OA是最常用的程序，它会改变关节上施加的应变和/或改变承重，导致关节不稳定并诱发OA。化学模型是通过关节内注射修饰因子或全身施用有害剂（如喹诺酮类）产生的。自发模型包括自然发生的模型和遗传模型。某些物种中描述了自然发生的OA，而遗传模型是通过基因操作开发的。总体而言，没有单一的动物模型适合研究退行性OA。然而，在本综述中，我们试图阐明每种模型的最合适用途。
