Rojas-Fernandez Carlos, Mikhail Mina
Can Pharm J (Ott). 2012 May;145(3):128-135.e2. doi: 10.3821/145.3.cpj128.
Late-life depression is common in older people. Its incidence increases significantly after age 70 to 85, as well as among those living in long-term care facilities. Depression contributes to excess morbidity and complicates management of comorbid conditions in older people. Diagnosis and management of depression often present clinicians with a challenge. Indeed, symptoms of depression in older people may not always be the same as those associated with depression in younger people. Additionally, age-related changes in pharmacokinetics and pharmacodynamics also impact selection, dosing, and monitoring of psychopharmacologic regimens. Optimizing management of depression and providing sound advice to older patients with depression requires knowledge and understanding of many clinical factors. The purpose of this review is to highlight salient issues in late-life depression, with a focus on the pharmacotherapy of depression.
老年期抑郁症在老年人中很常见。其发病率在70至85岁后以及长期护理机构中的人群中显著增加。抑郁症会导致老年人发病率过高，并使共病情况的管理复杂化。抑郁症的诊断和管理常常给临床医生带来挑战。事实上，老年人抑郁症的症状可能并不总是与年轻人抑郁症的症状相同。此外，药代动力学和药效学方面与年龄相关的变化也会影响精神药物治疗方案的选择、剂量和监测。优化抑郁症的管理并为老年抑郁症患者提供合理建议需要了解和认识许多临床因素。本综述的目的是突出老年期抑郁症的突出问题，重点是抑郁症的药物治疗。
