Department of Neurology, The Affiliated Wuxi Second Hospital, Nanjing Medical University, Wuxi, Jiangsu, China.
Int J Neurosci. 2013 Sep;123(9):626-35. doi: 10.3109/00207454.2013.784286. Epub 2013 Apr 23.
The -174G/C polymorphism in interleukin 6 (IL-6) gene has been extensively investigated for association to Alzheimer's disease (AD); however, results of different studies have been inconsistent. The objective of this study is to assess the relationship of IL-6 -174G/C polymorphism and Alzheimer's disease (AD) risk by using meta-analysis.
All eligible case-control studies were searched in PubMed and EMBASE. Odds ratios (ORs) with the 95% confidence intervals (CIs) were used to assess the association.
A total of 5316 cases and 10 757 controls in 21 case-control studies were included. Obvious heterogeneity among studies was detected, and no significant association was observed between the IL-6 -174G/C polymorphism and AD risk. After exclusion of three studies, the heterogeneity disappeared and significant association was observed between the polymorphism and AD risk in Asians (CC vs. CG+GG: OR = 0.5; 95%CI, 0.33-0.75) but not in Caucasians.
This meta-analysis suggested that the -174G/C polymorphism of IL-6 gene would be a protective risk factor for AD in Asians. To further evaluate gene-to-gene and gene-to-environmental interactions between polymorphisms of IL-10 gene and AD risk, more studies with large groups of patients are required.
白细胞介素 6（IL-6）基因-174G/C 多态性与阿尔茨海默病（AD）的相关性已被广泛研究；然而，不同研究的结果并不一致。本研究旨在通过荟萃分析评估 IL-6-174G/C 多态性与阿尔茨海默病（AD）风险的关系。
在 PubMed 和 EMBASE 中搜索所有合格的病例对照研究。使用优势比（ORs）及其 95%置信区间（CIs）来评估相关性。
共纳入 21 项病例对照研究的 5316 例病例和 10757 例对照。研究之间存在明显的异质性，IL-6-174G/C 多态性与 AD 风险之间无显著相关性。排除 3 项研究后，异质性消失，该多态性与亚洲人群 AD 风险相关（CC 与 CG+GG：OR=0.5；95%CI，0.33-0.75），但与高加索人群无关。
本荟萃分析表明，IL-6 基因-174G/C 多态性可能是亚洲人群 AD 的保护性风险因素。为了进一步评估 IL-10 基因多态性与 AD 风险之间的基因-基因和基因-环境相互作用，需要更多的大样本患者研究。
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